Radiology：动态对比增强和动态敏感对比磁共振在脑胶质瘤的多中心标准化评估。

2018-04-02 shaosai MedSci原创

评估在多中心临床环境下动态对比增强（DCE）和动态磁敏感对比（DSC）磁共振（MR）成像采集和分析的标准化方案的可行性，并根据新的世界卫生组织2016年分类验证其对于胶质瘤级别预测的准确性。

目的评估在多中心临床环境下动态对比增强（DCE）和动态磁敏感对比（DSC）磁共振（MR）成像采集和分析的标准化方案的可行性，并根据新的世界卫生组织2016年分类验证其对于胶质瘤级别预测的准确性。

材料和方法当地研究伦理委员会批准了该研究，并且获得了患者的知情同意。100名胶质瘤患者在7个中心的3.0T机器上进行了相同的术前磁共振成像协议扫描，包括DCE和DSC序列。两个独立的阅片者来识别判定在体积转移常数图上的关注热点（K trans），血浆（v p）和血管外细胞间隙（v e）容积，浓度曲线下的初始面积和相对脑血容量（rCBV）。通过使用Kruskal-Wallis和Mann-Whitney U检验来评估其等级和分子亚型之间的参数差异。采用受试者工作特征曲线分析评估诊断准确性。

结果。整个扫描方案被所有患者接受。 94例患者成功获得了灌注图。阅片者间对于DSC和DCE相关（measure）测量的重复性很好。DCE相关参数，v p和v e对于胶质瘤分级具有最高的准确性（在受试者工作特征曲线下[A z] = 0.847和0.853）。DSC相关rCBV的准确度最高（A z = 0.894），但差异无统计学意义（P> 0.05）。在低级别胶质瘤中，异柠檬酸脱氢酶野生型肿瘤中v p和rCBV均适度增加，但这并不显着（P> 0.05）。

结论 DCE和DSC MR成像的标准化多中心采集和分析方案是可行和高度可重复的。两种技术都显示出对胶质瘤分级的可比较的高诊断准确性。

原始出处：

Anzalone N， Castellano A， Cadioli M. et al.Brain Gliomas Multicenter Standardized Assessment of Dynamic Contrast-enhanced and Dynamic Susceptibility Contrast MR Images.Radiology.DOI： 10.1148/radiol.2017170362

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#多中心#

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2018-04-04 1696533704_45270454

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2018-04-04 txqjm

谢谢了.学习

52 0
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2018-04-03 龙胆草

学习谢谢分享

66 0
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2018-04-03 1dd8c52fm63(暂无匿称)

学习学习.继续关注

67 0
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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Apr 03 05:28:39 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
2018-04-03 lofter

学习了感谢分享

62 0
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2018-04-03 1e145228m78(暂无匿称)

学习了.谢谢作者分享!

64 0
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createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Apr 03 07:48:51 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302297, encodeId=dcdc30229e8f, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Apr 03 07:06:31 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302256, encodeId=5aa1302256a2, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Apr 03 05:28:39 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
2018-04-03 121832a9m88暂无昵称

学习了

30 0
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2018-04-03 yjs木玉

好好好好好好好好

30 0

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