Sleep Breath:CPAP在阻塞性呼吸暂停病人中的影响:过敏性鼻炎与之相关么?

2017-05-23 AlexYang MedSci原创

最近,有研究人员比较了睡眠窒息症病人中,持续气道正压通气(CPAP)对患有或者不患有过敏性鼻炎(AR/non AR)病人的影响。研究人员设计了一个预期的和纵向的研究。研究包括了34名持续性CPAB治疗的OSA病人,并且他们中17名有过敏性鼻炎,17名不患有过敏性鼻炎。在治疗前和治疗后2个月,研究人员评估了他们的临床参数(耳鼻喉症状、日间嗜睡度、总的鼻炎相关生活品质)、解剖学参数(耳鼻喉检查)、功能

最近,有研究人员比较了睡眠窒息症病人中,持续气道正压通气(CPAP)对患有或者不患有过敏性鼻炎(AR/non AR)病人的影响。研究人员设计了一个预期的和纵向的研究。研究包括了34名持续性CPAB治疗的OSA病人,并且他们中17名有过敏性鼻炎,17名不患有过敏性鼻炎。在治疗前和治疗后2个月,研究人员评估了他们的临床参数(耳鼻喉症状、日间嗜睡度、总的鼻炎相关生活品质)、解剖学参数(耳鼻喉检查)、功能参数(听觉功能、咽鼓管功能、鼻腔气流和粘液纤毛清除)以及生物学参数。并且在研究期间没有进行加湿或者抗过敏药物的使用。

研究结果表明,在鼻炎症状、耳科学症状、皮肤/眼部症状、免疫球蛋白E和鼻中粒性细胞方面,患有AR病人在处理前与nonAR病人比较具有更高得分。而在处理后,nonAR和AR组病人的日间嗜睡度有所改善(11.53 ± 4.60 vs. 7.53 ± 2.87, p = 0.000 and 13.76 ± 4.93 vs. 7.53 ± 4.41, p = 0.001),并且鼻中性粒细胞数目增加(0.16 ± 0.39 vs. 5.78 ± 9.43, p = 0.001 and 14.42 ± 31.94 vs. 79.47 ± 202.08, p = 0.035)。另外,AR病人的症状和生活品质有所改善。而在nonAR病人中,鼻干(1.65 ± 1.27 vs. 0.00, p = 0.002)和粘液纤毛清除次数(38.59 ± 24.90 vs. 26.82 ± 23.18, p = 0.01)也具有显著的增加。最后,研究人员指出,CPAP产生炎症是通过在AR和nonAR病人中增加鼻中性粒细胞实现的。尽管如此,患有AR的病人的鼻子症状和生活品质得到了改善,然而在不患有AR的病人中,鼻干和黏膜纤毛运动情况却变得更加糟糕。

原始出处:

Cisternas A, Aguilar F, Montserrat JM et al. Effects of CPAP in patients with obstructive apnoea: is the presence of allergic rhinitis relevant?. Sleep Breath. 10 May 2017.

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    2018-03-23 tomyang96
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