Gastroenterology:大锯齿状息肉对异时大锯齿状息肉和高危腺瘤风险的影响

2017-09-24 zhangfan MedSci原创

研究认为,大锯齿状息肉增加患者异时锯齿状息肉风险,但不影响患者的异时高危腺瘤风险;高危腺瘤并发锯齿状息肉显著提高患者异时高危腺瘤风险。对于高危腺瘤患者应加强对疾病的监控,预防癌变恶化

目前锯齿状息肉(SPS)的临床指南所包含的病人预后纵向数据十分有限。近日研究人员利用新罕布什尔州结肠镜检查中心检测数据评估了锯齿状息肉的临床异时性病变风险。

研究人员自2004年起收集新罕布什尔州患者结肠镜检查数据,包含腺瘤和锯齿状息肉检出率,参与者完成问卷以确定其社会人口学特征、健康史和大肠癌危险因素。共5433人参与本次研究,平均年龄61岁,男性占49.7%,平均进行了2次结肠镜检查,平均随访4.9年。研究采用多变量逻辑回归模型评价锯齿状息肉(SP,N = 1016),高危腺瘤(HRA,N = 817),低危腺瘤(N = 1418),无腺瘤(N = 3198)对随后结肠镜检查确证的HRA或超过1cm的大SPS(异时性病变)的影响。亚组分析中同时进行SPS大小和组织学评估。锯齿状息肉包括增生性息肉,无蒂锯齿状腺瘤/息肉(SSA / PS)和传统锯齿状腺瘤,统称为STSAS。

研究发现,高危腺瘤并发大锯齿状息肉(OR, 5.61; 95% CI, 1.72-18.28)、或并发STSAS(OR, 16.04; 95% CI, 6.95-37.00)以及单独的高危腺瘤(OR, 3.86; 95% CI, 2.77-5.39)均显著提高患者异时性病变风险。大锯齿状息肉(OR=14.34; 95% CI, 5.03-40.86)或STSA(OR, 9.70; 95% CI, 3.63-25.92)显著提高异时锯齿状息肉风险。

研究认为,大锯齿状息肉增加患者异时锯齿状息肉风险,但不影响患者的异时高危腺瘤风险;高危腺瘤并发锯齿状息肉显著提高患者异时高危腺瘤风险。对于高危腺瘤患者应加强对疾病的监控,预防癌变恶化。

原始出处:


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    2017-11-01 许安
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  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:24 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-26 luominglian113

    学习了.谢谢分享

    0

  6. 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  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:24 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-25 lietome15

    认真学习.不断进步.把经验分享给同好.点赞了!

    0

  8. 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createdBy=e2dd327, createdName=许安, createdTime=Wed Nov 01 18:47:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079194, encodeId=24dc20e9194ee, content=<a href='/topic/show?id=d2726808307' target=_blank style='color:#2F92EE;'>#状息肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68083, encryptionId=d2726808307, topicName=状息肉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Fri Sep 29 20:47:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711204, encodeId=766f1e1120432, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Nov 14 10:47:00 CST 2017, time=2017-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247962, encodeId=8bd724e962cd, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Tue Sep 26 21:35:54 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504327, encodeId=5a37150432e1a, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Sep 26 00:47:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247565, encodeId=b11624e565a6, content=认真学习.不断进步.把经验分享给同好.点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Mon Sep 25 10:29:06 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247307, encodeId=984f24e307df, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:24 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 131****1460

    学习了受益匪浅

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Sep 24 13:59:26 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247300, encodeId=86fc24e3002c, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Sep 24 12:46:45 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247281, encodeId=fe5f24e281b9, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:24 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 清风拂面

    谢谢分享.学习了

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Sep 24 13:59:26 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247300, encodeId=86fc24e3002c, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Sep 24 12:46:45 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247281, encodeId=fe5f24e281b9, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:24 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0