JAMA INTER MED:妊娠糖尿病可作为心血管疾病风险因素

2017-10-17 海北 MedSci原创

已有的研究发现妊娠糖尿病(GD)可以作为心血管疾病(CVD)中间标志物的危险因素。但是很少有前瞻性的研究,或是将两种疾病涉及的共同风险因素,包括体重和生活方式,考虑进入研究中。

已有的研究发现妊娠糖尿病(GD)可以作为心血管疾病(CVD)中间标志物的危险因素。但是很少有前瞻性的研究,或是将两种疾病涉及的共同风险因素,包括体重和生活方式,考虑进入研究中。 近日,来自哈佛大学的研究人员前瞻性地评估了GD病史和CVD风险之间的联系。其使用了护士健康研究II(NHS II),一项1989年成立的对美国女性护士进行的观察性队列研究。两年一次的调查表会更新参与者的行为特征,健康结果和生活方式因素。研究人员使用多变量Cox模型估计了CVD风险的风险比(HR)和95%CI。其共招募了89479名妇女,这些妇女报告至少1次怀孕,且基线时没有CVD和癌症。GD患病史的基线是在1989年通过问卷自我报告得出的,并且每两年更新一次。 研究人员观察到1161例自发报告的非致命或致命性心肌梗死或中风,并通过医疗记录确认。参与者的平均(SD)年龄为34.9(4.7)岁。调整年龄,妊娠体重指数和其他协变量,有无GD患病史和后续发展CVD相关 (HR, 1.43; 95% CI, 1.12-1.81)。怀孕后体重增加的附加调整和生活方式改变的因素减弱了这种关联性 (HR, 1.29; 95%

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254047, encodeId=fe0525404ed1, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Wed Oct 18 14:48:43 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254040, encodeId=5070254040ee, content=糖尿预测心血管--, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Oct 18 14:27:21 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253659, encodeId=8ec925365955, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Oct 17 08:49:53 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253650, encodeId=f452253650c9, content=很好很好很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Tue Oct 17 08:19:15 CST 2017, time=2017-10-17, status=1, ipAttribution=)]
    2017-10-27 yfjms

    学习

    0

  2. 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createdName=2227437833_79976374, createdTime=Tue Oct 17 08:19:15 CST 2017, time=2017-10-17, status=1, ipAttribution=)]
    2017-10-22 yfjms

    学习

    0

  3. 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createdName=2227437833_79976374, createdTime=Tue Oct 17 08:19:15 CST 2017, time=2017-10-17, status=1, ipAttribution=)]
    2017-10-20 kalery

    好文章学习了

    0

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  7. 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createdName=2227437833_79976374, createdTime=Tue Oct 17 08:19:15 CST 2017, time=2017-10-17, status=1, ipAttribution=)]
    2017-10-18 戒馋,懒,贪

    谢谢分享

    0

  8. 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createdName=2227437833_79976374, createdTime=Tue Oct 17 08:19:15 CST 2017, time=2017-10-17, status=1, ipAttribution=)]
    2017-10-18 sunfeifeiyang

    糖尿预测心血管--

    0

  9. 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14:27:21 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253659, encodeId=8ec925365955, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Oct 17 08:49:53 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253650, encodeId=f452253650c9, content=很好很好很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, 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    2017-10-17 Y—xianghai

    学习了新知识

    0

  10. 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createdName=2227437833_79976374, createdTime=Tue Oct 17 08:19:15 CST 2017, time=2017-10-17, status=1, ipAttribution=)]
    2017-10-17 2227437833_79976374

    很好很好很好

    0

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