Microbiome:研究揭示糖尿病的又一类重要诱因!

2018-02-20 佚名 medicalxpress

科学家已经发现,针对肠道中的微生物(称为微生物群)可能有助于预防1型糖尿病。

科学家已经发现,针对肠道中的微生物(称为微生物群)可能有助于预防1型糖尿病

昆士兰大学研究人员艾玛哈密尔顿 - 威廉姆斯博士研究了肠道微生物群的差异,将那些易患1型糖尿病的人与那些被保护免受自身免疫性疾病的人进行了比较。

她说:“这项研究表明,微生物群和参与调节它的免疫反应有遗传因素。”

“这意味着在出现症状之前,1型糖尿病的微生物群发生变化,而不仅仅是这种疾病的副作用。”

"针对微生物群的治疗可能会在未来帮助预防1型糖尿病。”

Hamilton-Williams博士说,这项研究还表明,针对1型糖尿病相关T细胞的免疫疗法导致了肠道生物学的急剧变化,并改变了小鼠模型中的微生物群。她说:“我们发现遗传易感性和免疫系统功能的改变导致了微生物群的改变。”

 “这意味着一个人的遗传因素会导致不健康的微生物以及他们的饮食。”

Hamilton-Williams博士说,参与该研究的研究人员调查了1型糖尿病小鼠模型中的微生物群和遗传易感性,并在英国进行了一项双胞胎人类研究。

Hamilton-Williams博士说,下一步是检查免疫疗法的临床试验,以确定在对治疗有积极反应的人群中微生物群是否改变。她表示,科学家们可以直接创建治疗方法,旨在将肠道微生物群恢复到健康状态,并开发更好的1型糖尿病治疗方法。

原始出处:

Jane A. Mullaney, Juliette E. Stephens, Mary-Ellen Costello, et.al. Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome 17 February 2018


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    2018-04-16 xjy02
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    2018-08-24 sunylz
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    2019-01-26 pyaili
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    2018-02-24 惠映实验室

    学习.谢谢分享.

    0

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    2018-02-21 忠诚向上

    努力学习.好好看下

    0

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    2018-02-21 Drhzm308

    谢谢.学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2084339, encodeId=af5f2084339ea, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Apr 16 00:00:00 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917933, encodeId=df15191e9339b, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Aug 24 06:00:00 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857582, encodeId=20f0185e582a0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sat Jun 16 02:00:00 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634162, encodeId=00821634162e6, content=<a href='/topic/show?id=4ffe11e09d8' target=_blank style='color:#2F92EE;'>#Microbiome#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11709, encryptionId=4ffe11e09d8, topicName=Microbiome)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39c822073631, createdName=pyaili, createdTime=Sat Jan 26 10:00:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290513, encodeId=8e3e29051371, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Feb 24 13:11:58 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289691, encodeId=3389289691c0, content=努力学习.好好看下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Feb 21 10:13:19 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289535, encodeId=07c2289535a3, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Feb 21 00:09:18 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289512, encodeId=4e8d289512c6, content=科学家已经发现.针对肠道中的微生物(称为微生物群)可能有助于预防1型糖尿病., beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Feb 20 20:56:33 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289482, encodeId=3f0628948226, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Feb 20 18:26:31 CST 2018, time=2018-02-20, status=1, ipAttribution=)]
    2018-02-20 有备才能无患

    科学家已经发现.针对肠道中的微生物(称为微生物群)可能有助于预防1型糖尿病.

    0

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    2018-02-20 131****1460

    学习了受益匪浅

    0

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