Sci Rep:非小细胞肺癌中IL-1β诱导的慢性炎症通过表观遗传修饰调节EMT记忆表型

2020-01-16 xiangting MedSci原创

化学抑制DNA甲基化不仅可以恢复EMT记忆的上皮钙粘蛋白表达,还可以引发化疗诱导的细胞凋亡。

慢性炎症促进肿瘤的进展。研究发现,非小细胞肺癌细胞亚群在暴露于IL-1β21天后逐渐发展为上皮-间充质(EMT)表型,而IL-1β是一种丰富存在于肺癌高危患者肺部和肺癌微环境中的促炎细胞因子。

基因表达谱的通路分析和体外功能研究表明,在没有持续IL-1β暴露的情况下,EMT和EMT相关表型(包括细胞侵袭增强、PD-L1上调和药物抗性)仍在持续。研究人员将此现象称为EMT记忆。利用多西环素对照的SLUG表达系统,研究发现转录因子SLUG的高表达对于建立EMT记忆是必不可少的。肺癌患者肿瘤中的SLUG高表达与存活率不良有关。对SLUG上调的化学或遗传抑制作用阻止了急性IL-1β暴露后的EMT,但并未逆转EMT记忆。染色质免疫沉淀和甲基化特异性PCR进一步揭示了SLUG介导的表观遗传修饰的时间调控,包括长期暴露于IL-1β后CDH1(上皮钙粘蛋白)启动子的H3K27、H3K9积累和DNA甲基化。

化学抑制DNA甲基化不仅可以恢复EMT记忆的上皮钙粘蛋白表达,还可以引发化疗诱导的细胞凋亡。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-09-17 HinsMax
  2. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 rgjl
  5. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 lfcmxl
  6. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 一叶知秋
  7. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 tastas
  8. [GetPortalCommentsPageByObjectIdResponse(id=1785187, encodeId=12be1e85187f8, content=<a href='/topic/show?id=00276e40e2' target=_blank style='color:#2F92EE;'>#EMT记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6740, encryptionId=00276e40e2, topicName=EMT记忆)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Sep 17 22:24:00 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075645, encodeId=d0e820e564576, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Sat Jun 20 06:24:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059862, encodeId=abdf20598625a, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Mar 23 06:24:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423868, encodeId=d1061423868dc, content=<a href='/topic/show?id=66d29650ac' target=_blank style='color:#2F92EE;'>#IL-1β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9650, encryptionId=66d29650ac, topicName=IL-1β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7ea3859416, createdName=rgjl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462132, encodeId=4aa51462132ef, content=<a href='/topic/show?id=c6436e385a' target=_blank style='color:#2F92EE;'>#EMT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6738, encryptionId=c6436e385a, topicName=EMT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f216475172, createdName=lfcmxl, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508261, encodeId=a01e150826157, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535252, encodeId=11df153525242, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569384, encodeId=558b1569384b8, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Sat Jan 18 02:24:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 zhangyxzsh

相关资讯

Cell Death Dis:间充质干细胞通过扩增MDSCs促进癌细胞存活转移

骨髓间充质干细胞(BMSCs)是一种能分化成多种细胞类型的多能基质干细胞。 BMSCs在化学指导下作用于癌细胞,并促进癌细胞微环境的形成。 BMSC的归巢受到多种因素的影响。远处器官(特别是骨髓)扩散的肿瘤细胞(DTCs)是癌症转移和复发的来源。 DTC的存活取决于微环境。在本研究中,研究人员旨在阐明受癌症改造的BMSCs是如何促进癌细胞在原发肿瘤部位和远处存活的。研究人员通过肿瘤内BMSCs和返

Sci Rep:ONECUT2过表达促进RAS驱动的肺腺癌进展

由正常沉默的组织-特异性基因激活驱动的异常分化导致细胞身份的转换,并通常导致癌症的进展。潜在的遗传和表观遗传学改变在很大程度上仍然未知。这里报告了肝胆、肠和神经特异性基因onecuthomeobox2(ONECUT2)在肺癌不同亚型中的异位激活。   ONECUT2表达与RAS驱动的肺腺癌预后不良相关。ONECUT2过表达在体外促进肿瘤生长和A549肺癌细胞的侵袭,在体内促进

Sci Rep:他汀类药物通过p53突变介导的细胞凋亡对肺腺癌有疗效

这些数据表明,在某些肺癌患者中使用他汀类药物具有临床益处。

韩宝惠:“盘”根究底,“肺”比寻常——2019年肺癌靶向治疗年度进展盘点

2019年仍然是肺癌治疗领域丰收的一年。新的治疗药物、治疗策略、治疗手段层出不全,为晚期非小细胞肺癌(NSCLC)患者的治疗提供了更多的选择。本文就今年晚期NSCLC患者靶向治疗领域进行盘点,以飨读者。1 新药物——创新药物助力新选择 1. EGFR通路 在EGFR这条通路,奥希替尼是目前唯一获批上市的三代EGFR-TKI类药物,无论是一线治疗还是后线治疗携带T790M突变的

张力:2019年肺癌免疫治疗年终盘点

方文峰,张力(中山大学肿瘤防治中心  内科,广州  510060) 【摘要】 免疫治疗的蓬勃发展为驱动基因阴性的患者带来了希望,肺癌的治疗格局正在经历革命性变革。笔者通过梳理2019年肺癌免疫治疗的研究报道,总结为下述6方面:①长生存:驱动基因阴性的非小细胞肺癌患者接受免疫单药二线治疗的5年生存率约为15%,一线治疗的5年生存率为23.2%,其中高表达程序性死亡蛋白配

NEJM:确诊9个月后死亡!这种皮疹极易误诊

看到皮疹,我们一般首先想的是皮肤科,但是,有时候皮疹的背后可能隐藏着呼吸科的严重问题。究竟什么情况下,皮疹要查肺癌呢?《新英格兰医学杂志》(NEJM)的这个病例会给我们很多启发。