Pediatrics:母乳喂养改善婴儿表观遗传

2018-09-28 小通 生物通

长期以来,人们一直认为,母乳喂养对母亲和婴儿有许多生理和心理健康益处,这些益处是由于母乳喂养引起的遗传变化吗?一项新研究证明了这种关联。

长期以来,人们一直认为,母乳喂养对母亲和婴儿有许多生理和心理健康益处,这些益处是由于母乳喂养引起的遗传变化吗?一项新研究证明了这种关联。

9月《儿科学》(Pediatrics)杂志报道了来自布朗大学Warren Alpert医学院教授、妇婴医院布朗中心主任Barry M. Lester博士课题组的一项研究,“我们发现,孕产妇护理可以改变婴儿应激生理反应相关基因活性,特别是调控激素皮质醇(cortisol)的释放。”

Lester博士和同事们观察了40多名足月健康婴儿与其母亲的互动,其中一半在五个月前都是母乳喂养,另一半没有。在母婴交互过程中,测量婴儿唾液中的皮质醇和调节糖皮质激素受体基因(参与代谢、发育和免疫应答)的DNA甲基化。

表明,母乳喂养与婴儿DNA甲基化减少以及皮质醇应激反应降低有关。换句话说,母乳喂养导致了婴儿的表观遗传学改善,这些婴儿比没有得到母乳喂养的婴儿较不容易有压力。

原始出处:Lester BM, Conradt E, LaGasse LL, et al. Epigenetic Programming by Maternal Behavior in the Human Infant. Pediatrics. 2018 Sep 26.

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    2019-02-25 feather89
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    2018-11-11 hbwxf
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    2018-09-30 villahu

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