J Hypertens:尿酸与血压有啥关系?

2017-05-20 xing.T MedSci原创

由此可见,较高的血清和尿液中尿酸浓度与较高的24小时MAP和高血压相关。这些结果表明血清和24尿液中尿酸浓度,后者作为尿酸生产的指标,相互独立,且均与血压和高血压相关。

增加的尿酸生产导致的活性氧积累已被建议作为尿酸和高血压之间相关性的一个可能机制。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员旨在评估血清尿酸浓度、24小时尿液中尿酸排泄,作为尿酸生产的指标,与24小时动态血压和高血压之间的相关性。

研究人员在2555名来自于马斯特里赫特研究的参与者[52%为男性,平均年龄为60±8.2岁;27%为2型糖尿病患者]中进行了一项横断面研究。研究人员采用多变量回归分析评估了血清尿酸和24小时尿酸排泄与24小时脉压、24小时平均动脉压(MAP)和高血压之间的相关性。

将传统的高血压危险因素进行调整后,血清尿酸浓度(每只SD为81 [mu]mol/L)与更高的24小时MAP[0.63mmHg;95%可信区间(CI)为0.27-1.00]以及高血压呈正相关(比值比为1.43;95%CI为1.27-1.61)。尿中尿酸排泄(每SD为140毫克/天/1.73平方米)与较高的24小时MAP相关(0.79mmHg;95%CI为0.46-1.12)和边界值显著与高血压相关(比值比为1.13;95%CI为1.02-1.25)。血清和24小时尿酸排泄与24小时脉压无显著相关性。上述相关性在性别或年龄上不存在相互作用。

由此可见,较高的血清和尿液中尿酸浓度与较高的24小时MAP和高血压相关。这些结果表明血清和24尿液中尿酸浓度,后者作为尿酸生产的指标,相互独立,且均与血压和高血压相关。

原始出处:

Timothy P. Murphy,et al. Uric acid and blood pressure: exploring the role of uric acid production in the Maastricht study.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Uric_acid_and_blood_pressure___exploring_the_role.97713.aspx

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    2017-11-29 feather89
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    2017-06-17 1e1a6940m50(暂无匿称)

    学习了

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhQkEvDREF6S2vZq3ZIpUYjdqicKVoAWaJSGoe8xNvS6o6QpmOlh2AQ7xuUpj8NiaDjJJgjbc7Xj3T6/0, createdBy=1c242047915, createdName=daiyaozu, createdTime=Sun May 21 08:20:18 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200727, encodeId=e4e9200e27d4, content=好文章谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun May 21 08:15:56 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200641, encodeId=cffd200641ba, content=值得推荐的好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun May 21 05:19:06 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-27 惠映实验室

    相互相连关系,并发症。

    0

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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun May 21 05:19:06 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 135****7952平儿

    学习了。。。。。。。。

    0

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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun May 21 05:19:06 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 有备才能无患

    较高的血清和尿液中尿酸浓度与较高的24小时MAP和高血压相关

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhQkEvDREF6S2vZq3ZIpUYjdqicKVoAWaJSGoe8xNvS6o6QpmOlh2AQ7xuUpj8NiaDjJJgjbc7Xj3T6/0, createdBy=1c242047915, createdName=daiyaozu, createdTime=Sun May 21 08:20:18 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200727, encodeId=e4e9200e27d4, content=好文章谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun May 21 08:15:56 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200641, encodeId=cffd200641ba, content=值得推荐的好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun May 21 05:19:06 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 130****4638

    尿酸和高血压的关系研究文献,不错。

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhQkEvDREF6S2vZq3ZIpUYjdqicKVoAWaJSGoe8xNvS6o6QpmOlh2AQ7xuUpj8NiaDjJJgjbc7Xj3T6/0, createdBy=1c242047915, createdName=daiyaozu, createdTime=Sun May 21 08:20:18 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200727, encodeId=e4e9200e27d4, content=好文章谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun May 21 08:15:56 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200641, encodeId=cffd200641ba, content=值得推荐的好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun May 21 05:19:06 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 daiyaozu

    学习了,不错

    0

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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun May 21 05:19:06 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 大爰

    好文章谢谢分享!!

    0

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    2017-05-21 189****1577

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