ANN SURG:食管癌术前放化疗后复发风险分层

2018-07-22 MedSci MedSci原创

关于食管癌术前放化疗后复发风险分层的报道很少。ANN SURG近期发表了一篇文章,建立了复发风险分层方法并研究其对新辅助放化疗后接受手术的食管癌患者术后监测的影响。

关于食管癌术前放化疗后复发风险分层的报道很少。ANN SURG近期发表了一篇文章,建立了复发风险分层方法并研究其对新辅助放化疗后接受手术的食管癌患者术后监测的影响。

在1998年到2014年间,601例食管癌患者接受新辅助放化疗后进行手术。作者分析了出现复发的模式,部位,时间,频率以及可能的预后因素。这一队列用作复发风险分层系统的训练队列,该分层进一步在另一个172例患者的队列中进行验证。研究结果表明,共150例患者在新辅助放化疗后出现病理性完全缓解(pCR),其余患者作为非病理性完全缓解组(non-pCR)。中位随访时间63.6个月,pCR组局部和远处复发率显着低于non-pCR组。根据独立预后因素将患者分为四个复发风险类型:pCR且临床Ⅰ/Ⅱ期,pCR且临床Ⅲ期,non-pCR且pN0和non-pCR且pN+,各型5年无复发生存率分别为88.7%,65.8%,55.3%和33.0%。在验证队列该分层同样有效。

文章最后认为,该研究发现了以病理学缓解和治疗前临床分期为基础的食管癌患者复发风险分层。可以针对不同风险的患者进行术后监测。

原始出处:
Xi Mian,Halleneire Christopher,et al.Recurrence Risk Stratification After Preoperative Chemoradiation of Esophageal Adenocarcinoma.ANN SURG.August 2018 doi:10.1097/SLA.0000000000002352

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    2018-07-24 yzh399
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    2018-07-24 zhouqu_8
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    2018-07-22 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

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    2018-07-22 wzb521zf

    一起学习学习

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