Gastric Cancer: 碘化钠转运体在胃癌中的功能分析及临床意义

2019-08-04 不详 MedSci原创

最近有研究表明碘化钠同向转运体(NIS)在肿瘤行为中具有重要作用。本研究的目的是研究NIS在调节肿瘤进展相关基因中的作用及其在胃癌(GC)中表达的临床病理学意义。

背景
最近有研究表明碘化钠同向转运体(NIS)在肿瘤行为中具有重要作用。本研究的目的是研究NIS在调节肿瘤进展相关基因中的作用及其在癌(GC)中表达的临床病理学意义。

方法
在人GC细胞系中,使用NIS siRNA进行敲除实验,并分析对增殖,存活和细胞运动的影响。使用微阵列分析检查细胞的基因表达谱。同时研究人员对从GC患者获得的145个原发肿瘤样品进行免疫组织化学分析。

结果
研究发现,NIS在MKN45和MKN74细胞中强烈表达。NIS的消耗抑制细胞增殖,迁移和侵袭并诱导细胞凋亡。微阵列分析的结果显示各种干扰素(IFN)信号传导相关基因,例如STAT1,STAT2,IRF1和IFIT1,在NIS耗尽的MKN45细胞中上调。此外,NIS的下调影响MAPK和NF-kB的磷酸化。免疫组织化学染色显示NIS主要位于癌细胞的细胞质或细胞膜中,其表达与组织学类型或静脉侵袭有关。预后分析显示,NIS的强烈表达与较短的术后生存时间相关。

结论
本项研究证实NIS通过影响IFN信号传导来调节肿瘤进展,并且其强烈表达与GC患者的预后较差有关。

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    2019-10-31 yzh409
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    2020-04-03 skhzy
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    2019-12-08 许安
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