SCI REP:血清尿酸水平与非高血压和糖尿病患者心血管疾病风险之间的关联!

2018-03-28 xing.T MedSci原创

由此可见,这些发现提醒研究人员注意健康成年人的心血管危险因素。

血清尿酸水平是心血管疾病(CVD)的危险因素。然而,它是否可以作为一个独立的危险因素仍然存在争议。近日,Scientific reports杂志上发表了一篇研究文章,研究人员分析了血清尿酸水平与心血管风险之间的关系。

总的来说,在宜兰衰老纵向研究中的973例无高血压糖尿病的参与者符合纳入研究的条件。根据尿酸水平受试者分为三组。研究人员使用Framingham风险评分(FRS)计算了10年的心血管风险。

研究人员发现血清尿酸水平处于最高三分位数的研究对象年龄较大,更有可能是男性,且有较高的收缩压、体重指数、颈动脉内膜中层厚度和血清甘油三酯、高敏C反应蛋白、低密度脂蛋白胆固醇水平以及较低的血清高密度脂蛋白胆固醇水平(所有P<0.05)。在血清尿酸水平处于最高三分位数的受试者具有较高的FRS(P<0.001)。调整其它危险因素后,血尿酸水平明显与FRS相关(P<0.05)。在多因素Logistic回归分析,血清尿酸水平可以独立地预测较高的(≥20%)FRS(比值比为1.33,95%可信区间为1.10–1.68)。

由此可见,这些发现提醒研究人员注意健康成年人的心血管危险因素。

原始出处:

Chun-Chin Chang,et al. Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22997-0

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    2018-04-02 小贝熊

    血清尿酸水平是心血管疾病(CVD)的危险因素.然而.它是否可以作为一个独立的危险因素仍然存在争议.谢谢分享

    0

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    2018-03-30 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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  6. 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content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Mar 28 13:32:36 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1819741, encodeId=1c161819e4198, content=<a href='/topic/show?id=bf8299e71a5' target=_blank style='color:#2F92EE;'>#非高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99771, encryptionId=bf8299e71a5, topicName=非高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f9279, createdName=slcumt, createdTime=Fri Jul 27 12:25:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301879, encodeId=9b203018e942, content=血清尿酸水平是心血管疾病(CVD)的危险因素.然而.它是否可以作为一个独立的危险因素仍然存在争议.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/27/6f2d63c799d68129300901eb0e962dd4.jpg, createdBy=ddf12178538, createdName=小贝熊, createdTime=Mon Apr 02 00:30:22 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301104, encodeId=bf1030110428, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Mar 30 07:22:44 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466363, encodeId=c7521466363fe, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/26/c866646b8c2ee22bfb4ebc0b871fd1ac.jpg, createdBy=39682158353, createdName=无怨无悔1, createdTime=Thu Mar 29 18:04:18 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300521, encodeId=ad20300521ef, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Wed Mar 28 14:06:07 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300519, encodeId=9ba4300519cf, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Mar 28 13:32:36 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-29 无怨无悔1

    学习了

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/26/c866646b8c2ee22bfb4ebc0b871fd1ac.jpg, createdBy=39682158353, createdName=无怨无悔1, createdTime=Thu Mar 29 18:04:18 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300521, encodeId=ad20300521ef, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Wed Mar 28 14:06:07 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300519, encodeId=9ba4300519cf, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Mar 28 13:32:36 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-28 zdvfsadb

    学习了

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/26/c866646b8c2ee22bfb4ebc0b871fd1ac.jpg, createdBy=39682158353, createdName=无怨无悔1, createdTime=Thu Mar 29 18:04:18 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300521, encodeId=ad20300521ef, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Wed Mar 28 14:06:07 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300519, encodeId=9ba4300519cf, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Mar 28 13:32:36 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-28 惠映实验室

    学习了.谢谢分享.

    0

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由此可见,SUA升高与IFG风险增加相关,在年龄处于中值以上的人群中,其也与代谢综合征和糖尿病有关。

Lancet Diabetes Endo:非诺贝特可降低II型糖尿病患者尿酸浓度,降低痛风发作风险

5年的长期研究认为,非诺贝特可降低20%的尿酸浓度,减少50%的痛风发作风险。非诺贝特可作为预防糖尿病痛风的有效辅助手段

防治痛风 控制尿酸水平是关键

过去人们常将痛风称为“富贵病”、“皇帝病”,但随着生活条件的改善,以及饮食结构的变化,痛风的发病呈现出年轻化的趋势,大众应该如何正确防治痛风呢?痛风是如何发生的?痛风是一种以高尿酸血症为基础的慢性、反复发作的疾病,属于关节炎的一种,又称代谢性关节炎或代谢性风湿病。急性痛风常在夜间发作,且多发于第一跖趾关节和踝、膝、腕关节,发作时关节部位出现红、肿、热、剧烈疼痛。疼痛常在24小时内达到峰值,随后逐渐

Hypertension:尿酸是高血压前期发展为高血压的风险标记!

由此可见,增加血清尿酸是高血压前期发展为高血压的较强风险标记。需要进一步的研究来明确高血压前期者针对高尿酸血症进行治疗是否可以阻止高血压发生。

Am J Kidney Dis:尿酸与CKD患者肾衰竭和死亡的风险分析!

由此可见,尿酸浓度是早期CKD患者肾功能衰竭的独立危险因素,与CKD患者的全因死亡率呈J型关系。在CKD中进行足够的随机安慰剂对照试验是必要的,以检验降低尿酸是否是预防CKD并发症和进展的有效方法。

JAHA:血清尿酸水平与老年人心血管疾病和全因死亡率之间的U形关系!

由此可见,SUA≥8或<4mg/dL可以独立预测老年人较高的全因和CVD相关死亡率,特别是营养不良者。