BJC：食管鳞癌患者的多学科治疗策略研究

2016-11-13 MedSci MedSci原创

食管局部晚期鳞状细胞癌(SCC)的标准治疗是顺铂结合5-氟尿嘧啶(CF-RT)的放化疗。这个多中心II期临床试验的对象为最初不能手术切除的局部晚期食管SCC患者，评估多烯紫杉醇+顺铂、5 -氟尿嘧啶(DCF)诱导化疗(ICT)和随后转换手术(CS)的安全性与有效性。研究纳入临床T4和/或不可切除的锁骨上淋巴结转移患者。开始治疗为三个周期的DCF-ICT，此后如果肿瘤可以切除，则进行CS；如

食管局部晚期鳞状细胞癌(SCC)的标准治疗是顺铂结合5-氟尿嘧啶(CF-RT)的放化疗。这个多中心II期临床试验的对象为最初不能手术切除的局部晚期食管SCC患者，评估多烯紫杉醇+顺铂、5 -氟尿嘧啶(DCF)诱导化疗(ICT)和随后转换手术(CS)的安全性与有效性。

研究纳入临床T4和/或不可切除的锁骨上淋巴结转移患者。开始治疗为三个周期的DCF-ICT，此后如果肿瘤可以切除，则进行CS；如果不能切除，则进行CF-RT，剂量为30–40 Gy，此后再次评估能否切除，如果能，则进行CS，如果不能，则完成60 Gy的CF-RT治疗。主要终点为1年总生存率(OS)。

共有48名患者参加研究，41.7%（n = 20）的患者进行了CS，包括DCF-CS (n=18)、DCF-CF-RT40Gy-CS (n=1)和DCF-CF-RT60Gy-CS (n=1)。19例（39.6%）为R0切除者。术后并发症等级大于或等于3的事件包括喉返神经麻痹、肺部感染、伤口感染、肺瘘、吞咽困难（各一例）；没有发现CS患者出现严重术后并发症。4例(8.3%)患者CF-RT后出现临床完全缓解。估计1年OS为67.9%，80%置信区间的下限为59.7%。接受DCF-CF-RT60Gy治疗的患者中，发生了1例与治疗相关的死亡。

食管局部晚期鳞状细胞癌患者，对于DCF-ICT后CS这种多学科综合治疗策略，有良好的耐受性和疗效。

原始出处：

Tomoya Yokota1, Ken Kato2, Yasuo Hamamoto3, Yasuhiro Tsubosa.Phase II study of chemoselection with docetaxel plus cisplatin and 5-fluorouracil induction chemotherapy and subsequent conversion surgery for locally advanced unresectable oesophageal cancer.British Journal of Cancer advance online publication 3 November 2016

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2017-05-31 木头人513

#鳞癌患者#

47 0
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2016-11-19 李东泽

很好，不错，以后会多学习

63 0
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2016-11-15 zhouqu_8

#食管#

35 0
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2016-11-15 zhouqu_8

#多学科#

43 0
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2016-11-15 1696533704_45270456

#鳞癌#

26 0

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