International Journal of Cardiology:P物质对急性心肌梗死模型的心肌保护作用

2018-08-12 王贵龙 罂粟花

P物质可通过减轻炎症反应而缓解心肌缺血-再灌注损伤程度,本研究旨在评估P物质对猪急性心肌梗死模型的心肌保护作用。

目 的

P物质可通过减轻炎症反应而缓解心肌缺血-再灌注损伤程度,本研究旨在评估P物质对猪急性心肌梗死模型的心肌保护作用。

方 法

本研究采用28只swine猪,结扎冠状动脉左前降支造成急性心肌梗死模型后,随机分为两组:试验组(group 1, n=14):再灌注前5min静脉注射P物质5 nmol/kg,对照组(group 2, n=14): 再灌注前5min静脉注射等剂量生理盐水;于实验开始时、第三天、第四周分别抽血,分别于第一周、第四周时测定心脏各功能指标,第四周时测定心肌梗死面积。

结 果

与group 2相比,group 1左室射血分数较高(37.9 ± 4.6% vs. 29.4 ± 3.2%, P=0.001),但第四周时无明显差异;与group 2相比,group 1心肌梗死面积明显减小(2.4±2.3% vs. 5.7±2.5%, P=0.020);与group 2相比,group 1第三周时血中性粒细胞/淋巴细胞比率明显减低,第四周时尿肌酐明显降低。

结 论

P物质可改善急性心肌梗死模型猪的早期左室射血分数,并减少心肌梗死面积,而且其可减轻炎症反应及急性心肌梗死后的缺血-再灌注损伤。

原始出处:

Doo Sun Sim, Weon Kim, Kyung Hye Lee. Cardioprotective effect of substance P in a porcine model of acute myocardial infarction. Int J Cardiol. 2018 May 31. pii: S0167-5273(18)32255-1. doi: 10.1016/j.ijcard.2018.05.113.

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    2018-10-22 般若傻瓜
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    2019-07-19 liye789132251
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    2018-08-13 liumin1987

    P物质的心肌保护作用。

    0

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    2018-08-12 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0