JAMA Neurol:超声聚焦丘脑切开术可显著缓解药物难治性震颤型帕金森病症状

2017-11-03 zhangfan MedSci原创

研究证实,对于震颤型帕金森病患者,接受超声聚焦丘脑切开术可显著缓解药物难治性震颤症状

临床试验已证实超声聚焦(FUS)可治疗特发性震颤,近日研究人员考察了其对于药物难治性震颤型帕金森病(TDPD)的治疗效果和安全性。

研究招募27名TDPD患者,随机(2:1)进行FUS丘脑切开术或模拟手术。研究的主要终点是3个月临床震颤评估变化,次要终点包括统一帕金森病评估(UPDRS)以及生活质量评估。

27名患者中,26人为男性,患者平均年龄67.8岁。FUS组临床震颤评估得分改善62%(基线得分17分)而对照组得分改善22%,(基线得分23分),组间差异显著。FUS 组UPDRS运动功能得分提高8分,而对照组得分提高1分。FUS组发生了2例内囊加热导致的轻度偏瘫,通过磁共振测温方法可以解决该问题,其他手术不良事件包括:4例口面部感觉异常、1例手指感觉异常以及1例共济失调。

研究证实,对于震颤型帕金森病患者,接受超声聚焦丘脑切开术可显著缓解药物难治性震颤症状。

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    2018-04-25 yinhl1978
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    2017-11-05 kalseyzl
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    2017-11-05 freve
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    2017-11-05 xlwang2696
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    2017-11-05 xlwang2696
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    2017-11-03 zt123

    从 v 改变 v 寸草春晖呢

    0

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