PLOS ONE:胆固醇水平和死亡率的队列研究

2018-04-21 海北 MedSci原创

众所周知的是,高胆固醇血症是冠心病的危险因素,但至今为止,我们对于胆固醇水平的变化与死亡率之间的关联尚未完全了解。

众所周知的是,高胆固醇血症是冠心病的危险因素,但至今为止,我们对于胆固醇水平的变化与死亡率之间的关联尚未完全了解。最近,来自韩国的研究人员调查了在基于人群的队列研究中,2年(2002 - 2003年至2004 - 2005年)胆固醇变化与全因和特定死亡率的关系。
研究人员使用了韩国国民健康保险服务 - 国家健康筛查队列,研究人群包括年龄超过40岁的269,391名参与者,无心肌梗死,中风和癌症。在第一次和第二次健康检查中,胆固醇水平从低到高被分为第1,2,3组。从2006年1月1日至2013年12月31日,研究人员对参与者进行了全因死亡和特定死因的跟踪。
与在第一次和第二次检查期间停留在第2个三分位的胆固醇组的参与者相比,在第二次检查期间成为或保持第1个三分位胆固醇水平的参与者具有增加的全因死亡率风险[调整后的风险比(aHR)和95%可信区间(95%CI)为 1/1= 1.28(1.18-1.38),2/1=1.16(1.07-1.26),3/1=1.47(1.32-1.64)]。此外,胆固醇水平升高或持续保持在第3个三分位组与全因死亡风险升高有关。
胆固醇水平降低或持续的低胆固醇水平与死亡风险的增加相关。特别是,胆固醇水平的自发降低可能是健康状况恶化的标志。

原始出处:
Jeong SM et al. Association of change in total cholesterol level with mortality: A population-based study. PLOS ONE, 2018; DOI:  10.1371/journal.pone.0196030

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    2018-04-24 衣带渐宽

    学习

    0

  3. 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    2018-04-21 执着追梦

    学习.谢谢分享

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Apr 21 08:39:59 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307828, encodeId=476f30e8286d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Apr 21 07:51:26 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307827, encodeId=05f130e82740, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Apr 21 07:47:15 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 哈哈869

    学了

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Apr 21 08:39:59 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307828, encodeId=476f30e8286d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Apr 21 07:51:26 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307827, encodeId=05f130e82740, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Apr 21 07:47:15 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 清风拂面

    谢谢分享学习

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Apr 21 08:39:59 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307828, encodeId=476f30e8286d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Apr 21 07:51:26 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307827, encodeId=05f130e82740, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Apr 21 07:47:15 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 戒馋,懒,贪

    谢谢分享学习了

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Apr 21 08:39:59 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307828, encodeId=476f30e8286d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Apr 21 07:51:26 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307827, encodeId=05f130e82740, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Apr 21 07:47:15 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Apr 21 07:47:15 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 龙胆草

    学习谢谢分享

    0

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objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Apr 21 07:47:15 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 明月清辉

    谢谢分享.学习了

    0

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    2018-04-21 kafei

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