Ann Rheum Dis:肉芽肿病伴多血管炎引起的终末期肾病患者肾移植后的生存率改善

2018-05-15 xiangting MedSci原创

肾移植与GPA导致的ESRD患者全因死亡率显著降低相关,这主要是由于CVD死亡风险降低。

肾移植是终末期肾病(ESRD)患者的最佳治疗方法。然而,由肉芽肿病伴多血管炎(GPA)引起的ESRD进行肾移植的生存获益尚不清楚。

研究人员在美国肾脏数据系统中查找1995年至2014年间由于GPA导致ESRD的患者(ESRD-GPA)。将分析限定在等待移植的受试者中以评估移植对死亡率的影响。对患者进行随访直到死亡或随访结束。使用汇总logistic回归模型,将移植作为随时间变化的暴露因素,比较了移植患者与非移植患者的全因死亡率和特异性死亡率的相对风险(RR)。

研究期间,1525名患者等待移植,946名患者接受了肾移植。在多因素调整分析中,接受肾移植与全因死亡风险降低70%相关(RR= 0.30,95%CI为0.25-0.37),这主要归因于心血管病(CVD)死亡风险降低90%(RR=0.10,95%0.06-0.16)。

肾移植与GPA导致的ESRD患者全因死亡率显著降低相关,这主要是由于CVD死亡风险降低。积极进行肾移植对于改善该类患者的预后十分重要。

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