Bull Exp Biol Med：内皮细胞调节间充质干细胞的分化潜能和迁移能力

2018-06-23 MedSci MedSci原创

本研究中，我们研究了内皮细胞对多潜能间充质基质细胞体外迁移和分化潜能的影响。结果显示，在存在完整的和TNFα激活的内皮细胞的情况下，干细胞基因OCT4，SOX2和成软骨分化调节剂SOX9基因下调，成骨主基因RUNX2在间充质基质细胞中上调，这表明间充质基质细胞承担能力增加。由内皮细胞调节的培养基刺激间充质基质细胞的迁移活性，与来自非活化细胞的培养基相比，来自活化细胞的条件培养基中的细胞迁移率明显增

本研究中，我们研究了内皮细胞对多潜能间充质基质细胞体外迁移和分化潜能的影响。

结果显示，在存在完整的和TNFα激活的内皮细胞的情况下，干细胞基因OCT4，SOX2和成软骨分化调节剂SOX9基因下调，成骨主基因RUNX2在间充质基质细胞中上调，这表明间充质基质细胞承担能力增加。由内皮细胞调节的培养基刺激间充质基质细胞的迁移活性，与来自非活化细胞的培养基相比，来自活化细胞的条件培养基中的细胞迁移率明显增加。

总之，该研究结果表明，与内皮细胞的相互作用调节了间充质基质细胞的功能活性。此外，激活的内皮细胞对直接接触和通过旁分泌调节的间充质基质细胞的分化潜能和迁移活性产生更明显的影响。

原始出处：

Zhidkova OV, Andreeva ER, Buravkova LB. Endothelial Cells Modulate Differentiation Potential and Mobility of Mesenchymal Stromal Cells. Bull Exp Biol Med. 2018 May;165(1):127-131. doi: 10.1007/s10517-018-4113-y. Epub 2018 May 24.

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2019-06-02 ms8888626721583891

#迁移#

0 0
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2018-11-01 12498ebem31暂无昵称

#Biol#

24 0
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2018-10-24 h.y200607_23674418

#间充质干细#

0 0
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2018-11-15 sunylz

#Bio#

33 0
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2018-06-24 ms3994565386320060

#Med#

29 0
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2018-06-24 龙胆草

学习谢谢分享

53 0
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2018-06-23 1209e435m98(暂无昵称)

学习了.谢谢分享

59 0
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2018-06-23 1dd8c52fm63(暂无匿称)

学习学习.继续关注

53 0
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2018-06-23 飛歌

学习了很有用

69 0

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