Sci Rep:在经历根治性切除术的尿路上皮癌患者中,淋巴血管侵入与淋巴结参与具有相似的预后

2018-11-08 AlexYang MedSci原创

最近,有研究人员确定了淋巴血管入侵(LVI)在患有膀胱癌且经历根治性切除术患者中的预后值。研究总共有747名患者经历了根治性切除术治疗。在这些患者中,只有164名没有经历淋巴结切除(LND)。研究人员将患者分成4个组:N0、N1、不具有LND的LVI组和没有LND的无LVI组。研究发现,N1组和LVI组患者具有显著更高的T阶段和等级,并且复发和致死率分别要高出1.5到2倍。在N1组中,与N0组和非

最近,有研究人员确定了淋巴血管入侵(LVI)在患有膀胱癌且经历根治性切除术患者中的预后值。

研究总共有747名患者经历了根治性切除术治疗。在这些患者中,只有164名没有经历淋巴结切除(LND)。研究人员将患者分成4个组:N0、N1、不具有LND的LVI组和没有LND的无LVI组。研究发现,N1组和LVI组患者具有显著更高的T阶段和等级,并且复发和致死率分别要高出1.5到2倍。在N1组中,与N0组和非LVI组相比,总生存(OS)明显更差(p=0.001和0.012);与N0组和非LVI组相比,LVI组也显著更差(p=<0.001和<0.001)。无复发生存(RFS)在N1组中比N0组和非LVI组显著更差(p=<0.001和<0.001);在LVI组中比N0组和非LVI组明显更差(p=<0.001和<0.001)。另外,在那些经历根治性切除术的患者中,由LVI预测的临床结果与那些通过淋巴结参与预测的结果相似。

最后,研究人员指出,新辅助化疗或者免疫治疗的作用也许需要在LVI阳性患者中进行重新评估,而不用考虑根治性切除术后的T阶段。

原始出处:


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    2018-11-10 sodoo
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    2018-11-10 jeanqiuqiu
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    2018-11-08 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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