抗骨质疏松药物阿仑膦酸钠该怎么吃,您知道吗?

2018-06-05 熊学惠 上海市第一人民医院临床药学科 上海药讯

对骨质疏松患者及药师来说,阿仑膦酸钠并不陌生,目前主要有两种规格,即10mg/片和70mg/片,前者每天服用一片,后者每周服用一片。但其服用方法往往会被患者漏记或错记,那么该药到底如何正确服用,本文将为大家详细讲解。

骨质疏松患者及药师来说,阿仑膦酸钠并不陌生,目前主要有两种规格,即10mg/片和70mg/片,前者每天服用一片,后者每周服用一片。但其服用方法往往会被患者漏记或错记,那么该药到底如何正确服用,本文将为大家详细讲解。

1.阿仑膦酸钠的适应证?

(1)适用于治疗绝经后妇女的骨质疏松症,以预防髋部和脊柱骨折(椎骨压缩性骨折);(2)适用于治疗男性骨质疏松以增加骨量;(3)适用于治疗糖皮质激素诱导的骨质疏松症。

2.如何正确服用阿仑膦酸钠?

该药服用方法是必须在每天(10mg/片)或每周固定的一天(70mg/片)第一次进食、喝饮料或应用其它药物治疗之前的至少半小时,用白水送服。因为其它饮料(包括矿泉水)、食物和一些药物有可能会降低其吸收。为尽快将药物送至胃部,降低对食道的刺激,应在清晨用一满杯白水送服,不可咀嚼或吸吮药片,以免出现口咽部溃疡,并且在服药后至少30分钟之内和当天第一次进食前,患者应避免躺卧,不应在就寝时和清晨起床前服用,否则会增加发生食道不良反应的危险。总结一句话:晨服直立多饮水,吃完溜达半小时。

3.阿仑膦酸钠有哪些不良反应?

在服用该药的患者中,已报告的食管不良反应有食管炎、食管溃疡和食管糜烂,罕有食管狭窄或食管穿孔的报告。故在用药过程中若出现吞咽困难、吞咽痛、胸骨后疼痛或新发胃灼热或胃灼热加重,需停药并就医。如果漏服了一次每周剂量,应在记起后的早晨空腹服用一片,不可在同一天服用两片,而应按其最初选择的日期计划,仍然每周服用一片。

口服阿仑膦酸钠的患者在拔牙和/或局部感染(包括骨髓炎),愈合延迟时,可能发生下颌骨坏死,也是由于其对牙齿的碳酸钙矿化基质所具有的强吸附能力,所以患者在使用该药物前,应先去口腔科检查是否有牙周病或其它口腔疾病,若需要接受侵入性牙外科手术(如拔牙、植牙)的患者,基于个体的获益风险评估,治疗医生和口腔外科医生的临床判断应指导临床治疗方案。如果患者使用该药物过程中,出现局部颌骨坏死需接受适当的口腔外科手术治疗,则应停药就医,进一步评估是否可以继续应用该药物。

4.服用阿仑膦酸钠还有哪些注意事项?

(1)对于轻中度肾功能不全患者(肌酐清除率35-60ml/min)无需调整剂量,重度肾功能不全患者(肌酐清除率小于35ml/min)不推荐使用本品。(2)在开始应用本品治疗之前,必须先纠正低钙血症。其它影响矿物质代谢的异常(例如维生素D缺乏),也应该得到有效治疗。对于这些病人,服药时应注意监测血清钙和低钙血症的情况。如食物中摄入不足,所有骨质疏松患者都应补充钙和维生素D,特别是使用糖皮质激素治疗的患者。(3)导致食管排空延迟的食管异常(例如狭窄或迟缓不能),或不能站立或坐直至少30分钟,或对本品任何成份过敏的患者禁用该药物。

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    2018-06-07 邓启付

    主要用于治疗和预防骨质疏松.

    0

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    2018-06-07 Eleven17
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    2018-06-06 131****1460

    学习了受益匪浅

    0

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    2018-06-06 131****1460

    学习了受益匪浅

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    2018-06-05 131****1460

    学习了受益匪浅

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    2018-06-05 13718711b3m

    学习了.获益匪浅.感谢分享

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