Heart:外伤性颅内出血与随后的房颤风险增加有关!

2017-04-09 xing.T MedSci原创

在这项大规模队列研究中,与对照组相比,创伤性ICH患者未来发生AF的风险更高。仔细监测AF的发生和适当的抗凝治疗对于创伤性ICH患者可能很重要。

外伤性颅内出血(ICH)可引起全身炎症反应和心律失常。心房颤动(AF)是最常见的心律失常,与全身炎症反应有关。然而,对于外伤性ICH和房颤之间的相关性证据有限。近日,在心脏病领域权威杂志Heart上针对这一问题发表了一篇研究文章。

该研究采用全民健康保险研究数据库,一个在台湾以人群为基础的队列,从2000到2011年期间,共有130171名外伤性ICH患者。此外,通过倾向得分法将无创伤性ICH的个人选入对照队列中。既往有AF的患者被排除在外。感兴趣的终点是AF的发生和因AF的发生而终止随访、失访或随访直至2011年12月31日。

在随访期间,外伤性ICH患者的房颤发生率明显高于非外伤性ICH患者(每1000人4.24 vs. 4.12人每年)。在调整年龄、性别和所有房颤相关合并症后,外伤性ICH患者房颤风险增加1.25倍(风险比为1.25,95%可信区间为1.18-1.32;P<0.001)。根据性别和年龄分层,外伤性ICH组AF的发生率一直较高。相比于无创伤性ICH和无合并症的患者,创伤性ICH伴有合并症的患者发生房颤的风险最高;并且这种风险高于只有外伤性ICH患者;它也同样高于那些仅有合并症的患者。

在这项大规模队列研究中,与对照组相比,创伤性ICH患者未来发生AF的风险更高。仔细监测AF的发生和适当的抗凝治疗对于创伤性ICH患者可能很重要。

原始出处:

Wei-Shiang Lin,et al. Traumatic intracranial haemorrhage is in association with an increased risk of subsequent atrial fibrillation. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2016-310451

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    2017-04-11 zhaojie88
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    2017-04-11 slcumt
  5. [GetPortalCommentsPageByObjectIdResponse(id=2022358, encodeId=2dab20223582a, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Mon Oct 16 16:59:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356219, encodeId=300f13562192b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532003, encodeId=0095153200396, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562479, encodeId=a9d015624e94e, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186405, encodeId=a0d218640569, content=学习过了,很棒的!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Apr 10 10:58:44 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186172, encodeId=0f8f1861e2f4, content=学习过了,很好值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 09 11:57:23 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186166, encodeId=56ba18616654, content=心房颤动(AF)是最常见的心律失常,与全身炎症反应有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Apr 09 11:28:23 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2017-04-10 明天会更好!

    学习过了,很棒的!!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2022358, encodeId=2dab20223582a, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Mon Oct 16 16:59:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356219, encodeId=300f13562192b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532003, encodeId=0095153200396, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562479, encodeId=a9d015624e94e, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186405, encodeId=a0d218640569, content=学习过了,很棒的!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Apr 10 10:58:44 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186172, encodeId=0f8f1861e2f4, content=学习过了,很好值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 09 11:57:23 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186166, encodeId=56ba18616654, content=心房颤动(AF)是最常见的心律失常,与全身炎症反应有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Apr 09 11:28:23 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2017-04-09 明天会更好!

    学习过了,很好值得分享!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2022358, encodeId=2dab20223582a, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Mon Oct 16 16:59:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356219, encodeId=300f13562192b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532003, encodeId=0095153200396, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562479, encodeId=a9d015624e94e, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Apr 11 01:59:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186405, encodeId=a0d218640569, content=学习过了,很棒的!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Apr 10 10:58:44 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186172, encodeId=0f8f1861e2f4, content=学习过了,很好值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 09 11:57:23 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186166, encodeId=56ba18616654, content=心房颤动(AF)是最常见的心律失常,与全身炎症反应有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Apr 09 11:28:23 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2017-04-09 榄枷檬

    心房颤动(AF)是最常见的心律失常,与全身炎症反应有关。

    0

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