Sci Tech Advan Materi:揭示新型人工骨支架可治疗骨损伤及弥补骨移植物缺陷

2012-07-27 T.Shen 生物谷

近日,来自韩国的研究者开发出的人工骨支架可以增强骨损伤的治疗并且可以弥补骨移植物所带来的缺陷。一般来讲,骨移植物需要特定材料来移植进入病人体内,人工移植使其更加容易和低风险,并且可以提供人工支架以支持骨生长。然而,发明出理想的特定材料比较困难,天然骨的结构在重量和强度上提供了一个最优化的选择,而且天然支架由于其疏松多孔,允许骨细胞向内生长。 文章中研究者发明了一种人工支架,可以模仿类似手指和脚趾

近日,来自韩国的研究者开发出的人工骨支架可以增强骨损伤的治疗并且可以弥补骨移植物所带来的缺陷。一般来讲,骨移植物需要特定材料来移植进入病人体内,人工移植使其更加容易和低风险,并且可以提供人工支架以支持骨生长。然而,发明出理想的特定材料比较困难,天然骨的结构在重量和强度上提供了一个最优化的选择,而且天然支架由于其疏松多孔,允许骨细胞向内生长。

文章中研究者发明了一种人工支架,可以模仿类似手指和脚趾小骨的结构,而且研究者也揭示了这种支架如何允许骨细胞有效的生长,满足了病人对力度和生物相容性的需求,相关研究成果刊登在了国际杂志Sceince and Technology of Advanced Materials上。

为了完成这个支架,研究者利用了两种不同的材料,这两种材料都是已经使用在人工骨上的陶瓷制品。第一种是羟磷灰石,可以促使骨细胞向内生长;另外一种是二氧化锆,这种材料足够结实,然而骨细胞不能在上面生长。这种新的支架具有层状结构,羟磷灰石在外表面用于促进骨细胞生长,二氧化锆在底下层,用于提供支持和力量。

为了检测骨细胞如何在这种新型支架上生长,研究小组分不同时间段在其表面培养了骨细胞,细胞可以在30分钟之内吸附至支架的表面并且可以持续吸附数天,然后在表面继续生长,并且进行分裂,一周之后,细胞可以覆盖支架整个表面,几乎填满了陶瓷结构的任何一个小孔。这种新型的人工骨支架弥补了当前人工支架的的不足,给病人带来了极大的便利。

编译自:Microwave Heating Improves Artificial Bone

doi:10.1088/1468-6996/13/3/035009
PMC:
PMID:

Microwave sintering and in vitro study of defect-free stable porous multilayered HAp–ZrO2 artificial bone scaffold

Dong-Woo Jang, Thi-Hiep Nguyen, Swapan Kumar Sarkar and Byong-Taek Lee

Continuously porous hydroxyapatite (HAp)/t-ZrO2 composites containing concentric laminated frames and microchanneled bodies were fabricated by an extrusion process. To investigate the mechanical properties of HAp/t-ZrO2 composites, the porous composites were sintered at different temperatures using a microwave furnace. The microstructure was designed to imitate that of natural bone, particularly small bone, with both cortical and spongy bone sections. Each microchannel was separated by alternating lamina of HAp, HAp–(t-ZrO2) and t-ZrO2. HAp and ZrO2 phases existed on the surface of the microchannel and the core zone to increase the biocompatibility and mechanical properties of the HAp-ZrO2 artificial bone. The sintering behavior was evaluated and the optimum sintering temperature was found to be 1400 °C, which produced a stable scaffold. The material characteristics, such as the microstructure, crystal structure and compressive strength, were evaluated in detail for different sintering temperatures. A detailed in vitro study was carried out using MTT assay, western blot analysis, gene expression by polymerase chain reaction and laser confocal image analysis of cell proliferation. The results confirmed that HAp-ZrO2 performs as an artificial bone, showing excellent cell growth, attachment and proliferation behavior using osteoblast-like MG63 cells.

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    2013-03-08 shock_melon
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    2013-02-23 howi
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1652070, encodeId=218416520e08b, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Mar 08 19:58:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745151, encodeId=2d671e45151e0, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 06 22:58:00 CST 2012, time=2012-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667134, encodeId=b936166e1344e, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Sat Feb 23 09:58:00 CST 2013, time=2013-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396708, encodeId=d3901396e08c8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560081, encodeId=633a15600819d, content=<a href='/topic/show?id=4ef810169912' target=_blank style='color:#2F92EE;'>#骨支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101699, encryptionId=4ef810169912, topicName=骨支架)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18f715064805, createdName=lixiaol, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566090, encodeId=4a2c15660903b, content=<a href='/topic/show?id=4ef810169912' target=_blank style='color:#2F92EE;'>#骨支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101699, encryptionId=4ef810169912, topicName=骨支架)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18f715064805, createdName=lixiaol, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620674, encodeId=f2be16206e417, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=)]
    2012-07-29 lixiaol
  6. [GetPortalCommentsPageByObjectIdResponse(id=1652070, encodeId=218416520e08b, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Mar 08 19:58:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745151, encodeId=2d671e45151e0, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 06 22:58:00 CST 2012, time=2012-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667134, encodeId=b936166e1344e, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Sat Feb 23 09:58:00 CST 2013, time=2013-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396708, encodeId=d3901396e08c8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560081, encodeId=633a15600819d, content=<a href='/topic/show?id=4ef810169912' target=_blank style='color:#2F92EE;'>#骨支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101699, encryptionId=4ef810169912, topicName=骨支架)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18f715064805, createdName=lixiaol, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566090, encodeId=4a2c15660903b, content=<a href='/topic/show?id=4ef810169912' target=_blank style='color:#2F92EE;'>#骨支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101699, encryptionId=4ef810169912, topicName=骨支架)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18f715064805, createdName=lixiaol, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620674, encodeId=f2be16206e417, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=)]
    2012-07-29 lixiaol
  7. [GetPortalCommentsPageByObjectIdResponse(id=1652070, encodeId=218416520e08b, content=<a href='/topic/show?id=13d01e24509' target=_blank style='color:#2F92EE;'>#TEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17245, encryptionId=13d01e24509, topicName=TEC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852f24292001, createdName=shock_melon, createdTime=Fri Mar 08 19:58:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745151, encodeId=2d671e45151e0, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 06 22:58:00 CST 2012, time=2012-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667134, encodeId=b936166e1344e, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Sat Feb 23 09:58:00 CST 2013, time=2013-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396708, encodeId=d3901396e08c8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560081, encodeId=633a15600819d, content=<a href='/topic/show?id=4ef810169912' target=_blank style='color:#2F92EE;'>#骨支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101699, encryptionId=4ef810169912, topicName=骨支架)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18f715064805, createdName=lixiaol, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566090, encodeId=4a2c15660903b, content=<a href='/topic/show?id=4ef810169912' target=_blank style='color:#2F92EE;'>#骨支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101699, encryptionId=4ef810169912, topicName=骨支架)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18f715064805, createdName=lixiaol, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620674, encodeId=f2be16206e417, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Sun Jul 29 01:58:00 CST 2012, time=2012-07-29, status=1, ipAttribution=)]