ATS2017:即使无COPD,吸烟者仍然面临着较高的死亡风险!

2017-05-24 枫丹白露 来宝网

在一项新的研究中,CT测量的血管修剪——远端肺血管(肺外缘血管)的减少与没有慢性阻塞性肺疾病(COPD)的吸烟者的死亡风险增加相关。该研究在2017年美国胸科协会国际会议上提出。

在一项新的研究中,CT测量的血管修剪——远端肺血管(肺外缘血管)的减少与没有慢性阻塞性肺疾病(COPD)的吸烟者的死亡风险增加相关。该研究在2017年美国胸科协会国际会议上提出。



“我们的研究结果表明,血管修剪可能是易受烟草烟雾伤害的重要标志物,并可能在轻度或无肺功能损害的吸烟者中提供预后信息,”Brigam和妇女医院的主任Carolyn E. Come医学博士说道。有趣的是,COPD吸烟者没有看到类似的信号。 “血管损伤可能在肺组织破坏之前,但是随着疾病的发展,两个过程同时进行,因此,在查看多个变量来预测死亡率的模型中,血管修剪的影响可能会被遮蔽,也可能血管修剪与死亡率的关联是非线性的。

Come博士及其同事使用CT扫描测量参与COPDGene研究的6,435例患者的血管结构(形态)。研究人员研究了一些变量来检查血管修剪与死亡率之间的关系。根据血管修剪量将患者分为四组(四分位数)。然后,他们将整个队列分成有和没有COPD的队列。

总体而言,3.8%的非COPD患者和18.8%的COPD患者在随访的5.6年之间死亡。在COPD和非COPD组中,科学家发现死亡率随着血管修剪的增加而增加。然而,在非COPD组中,经过多次变量调整后,修剪最多的患者死亡率明显高于最低修剪的患者。在COPD患者中,血管修剪与调整变量后分析的死亡率没有显着相关性。

Come博士说:“我们对吸烟者肉眼观察血管变化的发现与以前的研究结果一致,这些研究证实了无气道阻塞的吸烟者肺动脉微血管进行了重塑。她补充说:“我们的工作扩展了这些研究的结果,再次证明了具有轻度或无肺功能损害的吸烟者的血管形态变化,并显示出这些变化的临床重要性。

原始出处:

Carolyn E. Come, Farbod N. Rahaghi, et al. Computed Tomographic Vascular Pruning Predicts Mortality in Smokers Without Chronic Obstructive Pulmonary Disease. American Thoracic Society (ATS)2017  Abstract 10283

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    2017-05-25 184****9840

    远离吸烟,珍爱生命。

    0

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    2017-05-24 cqykthl

    吸烟这么多坏处,政府为啥还不控烟,就是因为其利润大么?

    0

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背景:美国心脏病学会和美国心脏学会(ACC/AHA) 的2013胆固醇管理指南推荐在所有20岁以上的成人中进行血脂筛查来识别动脉粥样硬化性心血管疾病(ASCVD)风险的增加。他汀类药物可被用于10年风险较高者(>5%) 或低密度脂蛋白胆固醇(LDL-C)水平≥4.92 mmol/L (190 mg/dL) 的患者。目的:本研究的目的是描述在小于50岁的非糖尿病成人中,心血管疾病风险升高的发生

Circulation:迄今为止大规模的冠心病「基因-吸烟」研究显示,吸烟简直就是作死

宾夕法尼亚大学的研究人员开展了一项涉及14.1万人的研究,终于找到了基因学证据来解释吸烟是如何导致冠心病的。吸烟会增加一种酶的产生,而这种酶会促进冠状动脉脂肪斑块的积聚,从而增加冠心病的患病风险[1]!

ATS 2017:吸烟者请注意:身体发生这一变化很可能是致命的!

吸烟会导致多种疾病。新的研究表明,胸部肌肉量越少,由于吸烟导致的死亡风险越高。来自疾病控制和预防中心(CDC)报告表示,吸烟是可预防疾病和死亡的第一大原因,