Ann Neurol:多发性硬化患者周围神经病变研究

2017-11-22 zhangfan MedSci原创

研究发现,多发性硬化患者存在磁共振可见的周围神经病变,患者子自旋密度增加和T2弛豫时间的减少,表明MS周围神经细胞外基质存在显微组织学改变。这一概念验证研究为MS的病理生理和治疗提供新的见解

近日研究人员通过磁共振成像定量检测多发性硬化症(MS)的外周神经病变。

36名MS患者参与研究,其中复发缓解型患者34人,临床孤立综合征患者2人。研究同时招募35名健康志愿者。所有参与者均进行神经系统和电生理检查。

所有MS患者均有T2W高信号的神经病变,平均病变数151.5±5.7 vs 19.1±2.4,MS患者神经质子自旋密度较高。与之相反,志愿者的T2弛豫时间较MS患者显著延长。MS患者胫骨近端(52.4±2.1mm2 vs 45.2±1.4mm2)和腓总神(25.4±1.3mm2 vs 21.3±0.7mm2)经管口径高于对照组。

研究发现,多发性硬化患者存在磁共振可见的周围神经病变,患者子自旋密度增加和T2弛豫时间的减少,表明MS周围神经细胞外基质存在显微组织学改变。这一概念验证研究为MS的病理生理和治疗提供新的见解。

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    2018-05-30 jml2009
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    2018-10-07 yinhl1978
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263337, encodeId=b6c326333e60, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Nov 22 11:04:32 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-12-01 飘飘爱

    很好

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263337, encodeId=b6c326333e60, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Nov 22 11:04:32 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-24 axin012
  6. 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263337, encodeId=b6c326333e60, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Nov 22 11:04:32 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-22 惠映实验室

    学习了.谢谢.

    0

  8. 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encodeId=9d6f26335ead, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Nov 22 13:16:55 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263343, encodeId=d229263343a1, content=MS患者周围神经也有损害, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Wed Nov 22 12:35:39 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263337, encodeId=b6c326333e60, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Nov 22 11:04:32 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-22 Y—xianghai

    学习了新知识

    0

  9. 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encodeId=9d6f26335ead, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Nov 22 13:16:55 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263343, encodeId=d229263343a1, content=MS患者周围神经也有损害, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Wed Nov 22 12:35:39 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263337, encodeId=b6c326333e60, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Nov 22 11:04:32 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-22 邓启付

    MS患者周围神经也有损害

    0

  10. 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encodeId=9d6f26335ead, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Nov 22 13:16:55 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263343, encodeId=d229263343a1, content=MS患者周围神经也有损害, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Wed Nov 22 12:35:39 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263337, encodeId=b6c326333e60, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Nov 22 11:04:32 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-22 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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研究表明,慢性疾病对多发性硬化的确诊以及患者生存具有显著影响

Neurology:多发性硬化患者并发症及对治疗的影响

研究认为,对于新发多发性硬化患者,并发症状态对治疗方案的选择和效果有一定的影响,临床实践中需要充分考量

Eur Radiol:脑血管反应性受损是否能作为多发性硬化患者认知功能下降的早期标记物?

脑血管反应性与认知状态的关系尚不明确。本研究旨在验证多发性硬化患者脑血管反应性潜在性减低及其与认知状态的相关性,并将结果发表在Eur Radiol上。

这种病如太阳黑子 令生活暗淡无光

多发性硬化(multiple sclerosis,MS)是一种主要累及中枢神经系统(CNS)白质并导致多部位髓鞘脱失的自身免疫性疾病,具有易复发和致残率高的特点,在西方国家发病率较高,有学者形容MS犹如太阳黑子一样使生活暗淡无光。