盘点:近期结直肠癌重大研究一览

2016-12-03 MedSci MedSci原创

我国结直肠癌的发病率和病死率均保持上升趋势。 2011年结直肠癌的发病率和病死率分别为23.03/10万和11.11/10万。其中,城市远高于农村,且结肠癌的发病率上升显著。 多数患者发现时已属于中晚期。 梅斯小编整理了近期结直肠癌重大研究,与大家分享。【1】BJC:KCNQ1是结直肠癌复发的预测因素结直肠癌(CRC)是世界范围内最常见的第三种癌症。准确识别II期CRC复发风险仍是临床一大挑战

我国结直肠癌的发病率和病死率均保持上升趋势。 2011年结直肠癌的发病率和病死率分别为23.03/10万和11.11/10万。其中,城市远高于农村,且结肠癌的发病率上升显著。 多数患者发现时已属于中晚期。 梅斯小编整理了近期结直肠癌重大研究,与大家分享。

【1】BJC:KCNQ1是结直肠癌复发的预测因素

结直肠癌(CRC)是世界范围内最常见的第三种癌症。准确识别II期CRC复发风险仍是临床一大挑战。

既往研究表明,KCNQ1基因是肿瘤抑制基因,该基因失去表达与CRC肝转移患者的不良预后相关。本研究调查KCNQ1对II期和III期CRC的预后价值。

利用微阵列基因表达数据,评估了90例II期结肠癌患者(AMC-AJCCII-90)的KCNQ1 mRNA表达情况。随后,使用免疫组化组织芯片评估386例II期和III期结肠癌患者的KCNQ1蛋白表达情况。

II期微卫星稳定(MSS)结肠癌患者中,低水平的KCNQ1 mRNA表达与较差的无病生存期(DFS)有关(P=0.025)。上皮细胞缺乏KCNQ1蛋白的表达与II期MSS (P<0.0001)、III期MSS(P=0.0001)和III期微卫星不稳定结肠癌患者(P=0.041)的较差的DFS有关。

除了诸如血管侵犯、淋巴结分期和微卫星不稳定状态等高危因素外,KCNQ1似乎也具有独立预后价值。

我们得出这样的结论:KCNQ1是疾病复发的预测生物标记物。(文章详见--BJC:KCNQ1是结直肠癌复发的预测因素

【2】Aliment Pharmacol Ther:NAFLD与结直肠癌风险

既往的研究表明,非酒精性脂肪性肝病(NAFLD)与结直肠癌风险存在相关性。但是NAFLD包括了从单纯性脂肪肝到肝纤维化脂肪性肝炎等不同程度的病理疾病。

研究目的是调查是否存在NAFLD、以及NAFLD的严重程度,与结直肠癌的风险间的联系。

研究纳入了26540例无症状的成年人,在同一天进行首次结肠镜检查和腹部超声检查。通过超声检查结果诊断参与者是否存在NAFLD。晚期结直肠肿瘤被定义为浸润性癌或腺瘤,直径至少10毫米,有高级别的不典型增生,或有绒毛组织学特征或其任何组合。NAFLD患者与非NAFLD患者比较,有较高的结直肠肿瘤((38.0% vs. 28.9%))和晚期结直肠肿瘤(2.8% vs. 1.9%)患病率。调整年龄、性别、吸烟、饮酒、体重指数、一级结直肠癌家族史、使用阿司匹林和代谢因素后的多变量模型表明,NAFLD患者与非NAFLD患者比较,结直肠肿瘤和晚期结直肠肿瘤的OR值分别为1.10 [95% CI: 1.03–1.17]和1.21 (95% CI: 0.99–1.47)。

根据病情的严重程度对NAFLD患者进一步分层,患有严重的肝脏疾病与轻度肝脏疾病患者比较,结直肠肿瘤或晚期结直肠肿瘤的风险更高。结果表明,存在NAFLD、以及NAFLD的严重程度,均与结直肠癌的风险密切相关。(文章详见--Aliment Pharmacol Ther:NAFLD与结直肠癌风险

【3】Aliment Pharmacol Ther:预防结直肠癌,阿司匹林是否优于结肠镜或FOBT?

使用阿司匹林、软式乙状结肠镜或愈创木脂粪便潜血试验(FOBT)筛查,均可以降低结直肠癌死亡率,但没有对这些干预措施的有效性进行比较。

本项网络荟萃分析比较了阿司匹林和软式乙状结肠镜或愈创木脂FOBT筛查对结直肠癌发病率和死亡率的影响。

我们检索了MEDLINE,EMBASE和Cochrane等数据库中相关的随机对照试验。随机试验报告了平均风险人群的结直肠癌死亡率、发病率或两者均有,且随访至少2年,样本量超过100。阿司匹林与FOBT (RR 1.03; 95% PrI 0.76–1.39)或软式乙状结肠镜检查(RR 1.16; 95% PrI 0.84–1.60)比较,结直肠癌死亡率方面的影响是相似的。预防近端结肠癌死亡方面,使用阿司匹林比FOBT (RR 0.36; 95% PrI 0.22–0.59)和乙状结肠镜检查(RR 0.37; 95% PrI 0.22–0.62)更有效。阿司匹林和筛查方法均可以减少结直肠癌发病率,不过乙状结肠镜检查优于FOBT (RR 0.84; 95% PrI 0.72–0.97)。降低结直肠癌的发病率和死亡率方面,低剂量阿司匹林似乎和软式乙状结肠镜或愈创木脂FOBT筛查同样有效,并且预防近端结肠癌症更有效。(文章详见--Aliment Pharmacol Ther:预防结直肠癌,阿司匹林是否优于结肠镜或FOBT?

【4】Cancer Med:比CEA敏感两倍:ctDNA监测结直肠癌复发有前途

近日,Cancer Medicine杂志发表的一项研究显示,与结直肠癌术后标准的监测标志物癌胚抗原CEA相比,基于血液中循环肿瘤DNA(ctDNA)的2个基因组合可以检测到两倍的复发病例。

ctDNA检测目标为BCAT1和IKZF1基因的甲基化,这种基因甲基化与肿瘤的生长和浸润密切相关。

来自澳大利亚佛林德斯大学癌症创新中心的研究者Graeme P.Young博士表示,考虑到至少有30%的结直肠癌患者在初始治疗后会复发,因此改进术后疾病监测方法,提高复发监测的准确性就显得尤为重要。

Young博士还说道:“该研究的结果强化了ctDNA在结直肠癌患者中检测的可靠性。另外还提示,当对处于缓解期的患者进行持续监测时,BCAT1/IKZF1检测阳性或可建立一种新的早期复发预警机制,以发现更多的可疑复发并促使早期影像学检查。针对BCAT1/IKZF1基因检测对比CEA检测的前瞻性研究正在进行中。”

在接受手术治疗的结直肠癌患者中,最终有30%~40%会出现复发,多见于治疗后2~3年内。(文章详见--Cancer Med:比CEA敏感两倍:ctDNA监测结直肠癌复发有前途

【5】陈功教授:解读2017版NCCN结直肠癌指南更新--左右半结肠癌之争入指南

2016年11月23日,NCCN在线发布了2017版结肠癌和直肠癌临床实践指南,和2016年V2版对比,还是出现了很多能改变临床实践的更新,尤其关于左右半的问题,由于以指南的形式第一次推荐将原发瘤部位纳入mCRC一线治疗中靶向药物的选择参考依据,这必将是里程碑式的更新,相信也会是引起轩然大波的更新。以下是陈功教授对2017版NCCN结直肠癌指南的可能会改变临床实践的主要更新做一解读。

2017版NCCN结直肠癌指南在"结肠癌长期随访保健计划"(PRINCIPLES OF SURVIVORSHIP - Colorectal Long-term Follow-up Care)章节的"生活方式和健康咨询"栏目里更新了推荐,"考虑低剂量阿司匹林"。并在指南最后的"讨论"文字稿部分专门增加了一个章节,"结直肠癌术后生存患者的二级化学预防",来阐述早期结直肠癌患者根治术后推荐口服低剂量阿司匹林的相关内容。

关于阿司匹林的防癌与抗癌效果,已经关注了很多年,既往主要研究集中在结直肠肿瘤领域,关注阿司匹林在结直肠癌化学预防领域的两大作用:减少健康人群中CRC的发生率(一级预防);减少罹患CRC者根治术后的肿瘤复发(二级预防);而阿司匹林在结直肠癌二级预防的价值,最有名的证据来自哈佛大学麻省总院(MGH)著名学者陈志辉(Andrew CHAN)领导的研究小组的发现,他们在2012年发现阿司匹林对结肠癌术后复发的预防可能与PIK3CA基因突变有关,该研究结果发表在当年的新英格兰医学杂志(Liao, X等,NEJM 2012),引发了全球对此的研究热潮。(文章详见--陈功教授:解读2017版NCCN结直肠癌指南更新--左右半结肠癌之争入指南

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    2016-12-16 南宫恨

    少了什么。。。。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1755002, encodeId=6f731e5500228, content=<a href='/topic/show?id=ec5995e752e' target=_blank style='color:#2F92EE;'>#重大研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95775, encryptionId=ec5995e752e, topicName=重大研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb4036811817, createdName=zz12341246, createdTime=Fri Aug 25 23:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163245, encodeId=defb1632453f, content=少了什么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAqNIYnFHJ2eOd2BNt54CBicqEp4BnzG2I3NibmvM2uD3XWHdMIbTTPnMWT9q23hqUGJP6XOyFmxGCg/0, createdBy=92b01994658, createdName=南宫恨, createdTime=Fri Dec 16 12:10:21 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160502, encodeId=b63e16050265, content=不错的东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ed71989741, createdName=1e1a0b86m39(暂无匿称), createdTime=Mon Dec 05 21:54:40 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452856, encodeId=02a3145285658, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Dec 05 09:33:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160146, encodeId=6a171601469f, content=有没有搞机制研究哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Sun Dec 04 10:06:45 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160103, encodeId=c2b21601035b, content=小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Dec 04 08:18:52 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160031, encodeId=7d1e16003188, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Sun Dec 04 00:03:22 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160010, encodeId=0ae2160010e3, content=很好的总结概括, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Dec 03 22:44:25 CST 2016, time=2016-12-03, status=1, ipAttribution=)]
    2016-12-05 1e1a0b86m39(暂无匿称)

    不错的东西

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1755002, encodeId=6f731e5500228, content=<a href='/topic/show?id=ec5995e752e' target=_blank style='color:#2F92EE;'>#重大研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95775, encryptionId=ec5995e752e, topicName=重大研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb4036811817, createdName=zz12341246, createdTime=Fri Aug 25 23:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163245, encodeId=defb1632453f, content=少了什么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAqNIYnFHJ2eOd2BNt54CBicqEp4BnzG2I3NibmvM2uD3XWHdMIbTTPnMWT9q23hqUGJP6XOyFmxGCg/0, createdBy=92b01994658, createdName=南宫恨, createdTime=Fri Dec 16 12:10:21 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160502, encodeId=b63e16050265, content=不错的东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ed71989741, createdName=1e1a0b86m39(暂无匿称), createdTime=Mon Dec 05 21:54:40 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452856, encodeId=02a3145285658, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Dec 05 09:33:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160146, encodeId=6a171601469f, content=有没有搞机制研究哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Sun Dec 04 10:06:45 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160103, encodeId=c2b21601035b, content=小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Dec 04 08:18:52 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160031, encodeId=7d1e16003188, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Sun Dec 04 00:03:22 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160010, encodeId=0ae2160010e3, content=很好的总结概括, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Dec 03 22:44:25 CST 2016, time=2016-12-03, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1755002, encodeId=6f731e5500228, content=<a href='/topic/show?id=ec5995e752e' target=_blank style='color:#2F92EE;'>#重大研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95775, encryptionId=ec5995e752e, topicName=重大研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb4036811817, createdName=zz12341246, createdTime=Fri Aug 25 23:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163245, encodeId=defb1632453f, content=少了什么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAqNIYnFHJ2eOd2BNt54CBicqEp4BnzG2I3NibmvM2uD3XWHdMIbTTPnMWT9q23hqUGJP6XOyFmxGCg/0, createdBy=92b01994658, createdName=南宫恨, createdTime=Fri Dec 16 12:10:21 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160502, encodeId=b63e16050265, content=不错的东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ed71989741, createdName=1e1a0b86m39(暂无匿称), createdTime=Mon Dec 05 21:54:40 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452856, encodeId=02a3145285658, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Dec 05 09:33:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160146, encodeId=6a171601469f, content=有没有搞机制研究哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Sun Dec 04 10:06:45 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160103, encodeId=c2b21601035b, content=小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Dec 04 08:18:52 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160031, encodeId=7d1e16003188, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Sun Dec 04 00:03:22 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160010, encodeId=0ae2160010e3, content=很好的总结概括, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Dec 03 22:44:25 CST 2016, time=2016-12-03, status=1, ipAttribution=)]
    2016-12-04 MyQueen

    有没有搞机制研究哒

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1755002, encodeId=6f731e5500228, content=<a href='/topic/show?id=ec5995e752e' target=_blank style='color:#2F92EE;'>#重大研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95775, encryptionId=ec5995e752e, topicName=重大研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb4036811817, createdName=zz12341246, createdTime=Fri Aug 25 23:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163245, encodeId=defb1632453f, content=少了什么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAqNIYnFHJ2eOd2BNt54CBicqEp4BnzG2I3NibmvM2uD3XWHdMIbTTPnMWT9q23hqUGJP6XOyFmxGCg/0, createdBy=92b01994658, createdName=南宫恨, createdTime=Fri Dec 16 12:10:21 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160502, encodeId=b63e16050265, content=不错的东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ed71989741, createdName=1e1a0b86m39(暂无匿称), createdTime=Mon Dec 05 21:54:40 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452856, encodeId=02a3145285658, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Dec 05 09:33:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160146, encodeId=6a171601469f, content=有没有搞机制研究哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Sun Dec 04 10:06:45 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160103, encodeId=c2b21601035b, content=小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Dec 04 08:18:52 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160031, encodeId=7d1e16003188, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Sun Dec 04 00:03:22 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160010, encodeId=0ae2160010e3, content=很好的总结概括, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Dec 03 22:44:25 CST 2016, time=2016-12-03, status=1, ipAttribution=)]
    2016-12-04 ylzr123

    小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1755002, encodeId=6f731e5500228, content=<a href='/topic/show?id=ec5995e752e' target=_blank style='color:#2F92EE;'>#重大研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95775, encryptionId=ec5995e752e, topicName=重大研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb4036811817, createdName=zz12341246, createdTime=Fri Aug 25 23:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163245, encodeId=defb1632453f, content=少了什么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAqNIYnFHJ2eOd2BNt54CBicqEp4BnzG2I3NibmvM2uD3XWHdMIbTTPnMWT9q23hqUGJP6XOyFmxGCg/0, createdBy=92b01994658, createdName=南宫恨, createdTime=Fri Dec 16 12:10:21 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160502, encodeId=b63e16050265, content=不错的东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ed71989741, createdName=1e1a0b86m39(暂无匿称), createdTime=Mon Dec 05 21:54:40 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452856, encodeId=02a3145285658, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Dec 05 09:33:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160146, encodeId=6a171601469f, content=有没有搞机制研究哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Sun Dec 04 10:06:45 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160103, encodeId=c2b21601035b, content=小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Dec 04 08:18:52 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160031, encodeId=7d1e16003188, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Sun Dec 04 00:03:22 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160010, encodeId=0ae2160010e3, content=很好的总结概括, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Dec 03 22:44:25 CST 2016, time=2016-12-03, status=1, ipAttribution=)]
    2016-12-04 慧读

    值得学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1755002, encodeId=6f731e5500228, content=<a href='/topic/show?id=ec5995e752e' target=_blank style='color:#2F92EE;'>#重大研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95775, encryptionId=ec5995e752e, topicName=重大研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb4036811817, createdName=zz12341246, createdTime=Fri Aug 25 23:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163245, encodeId=defb1632453f, content=少了什么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAqNIYnFHJ2eOd2BNt54CBicqEp4BnzG2I3NibmvM2uD3XWHdMIbTTPnMWT9q23hqUGJP6XOyFmxGCg/0, createdBy=92b01994658, createdName=南宫恨, createdTime=Fri Dec 16 12:10:21 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160502, encodeId=b63e16050265, content=不错的东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ed71989741, createdName=1e1a0b86m39(暂无匿称), createdTime=Mon Dec 05 21:54:40 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452856, encodeId=02a3145285658, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Dec 05 09:33:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160146, encodeId=6a171601469f, content=有没有搞机制研究哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Sun Dec 04 10:06:45 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160103, encodeId=c2b21601035b, content=小编辛苦了!为我们整理如此齐全的资料,供学习探究。点赞啦!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Dec 04 08:18:52 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160031, encodeId=7d1e16003188, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Sun Dec 04 00:03:22 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160010, encodeId=0ae2160010e3, content=很好的总结概括, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Dec 03 22:44:25 CST 2016, time=2016-12-03, status=1, ipAttribution=)]
    2016-12-03 oo902

    很好的总结概括

    0

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