JCEM:小学和中学肥胖儿童合并症情况以及对生活方式干预的反应

2019-02-20 xing.T 网络

由此可见,在肥胖的小学儿童中合并症的存在已经很明显。与中学生相比,生活方式干预对这些合并症的影响更大,强调需要早期干预。

儿童肥胖会增加患糖尿病血管疾病和非酒精性脂肪肝等疾病的风险。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估学龄期肥胖儿童合并症的患病率,并比较其在中小学时期以及男孩与女孩之间的患病率程度,并观察生活方式干预的效果。

该研究包含横断面分析和生活方式干预,是在超重青少年和儿童保健中心完成。研究人员对149名小学和150名中学(肥胖)儿童(162名女孩)的合并症进行了评估,分析了82名小学和75名中学儿童的生活方式干预效果。主要的生活干预为一年的跨学科生活方式干预。

在小学儿童中胰岛素抵抗(37%)、葡萄糖耐量降低(IGT)(3%)、血脂异常(48%)、高血压(7%)和肝转氨酶水平升高(54%)已经很常见。肾小球高滤过和胰岛素抵抗在中学儿童中更为普遍。IGT在女孩中更为普遍。干预后BMI z评分的变化在小学儿童中更高(小学与中学:-0.25±0.32 vs. 比-0.11±0.47),即使LDL胆固醇浓度的变化也一样(小学与中学:-0.30(-0.70至0.10)vs. -0.10(-0.40至0.30))和收缩压z-得分(小学与中学:-0.32±1.27 vs. 0.24±1.3)。在男孩中BMI z评分的变化更大,但合并症则不然(男孩与女孩:-0.33±0.45 vs. -0.05±0.31)。

由此可见,在肥胖的小学儿童中合并症的存在已经很明显。与中学生相比,生活方式干预对这些合并症的影响更大,强调需要早期干预。

原始出处:

Kylie Karnebeek.et al.Comorbidities in primary versus secondary school children with obesity and responsiveness to lifestyle intervention.J Clin Endocrinol Metab. 2019.https://doi.org/10.1210/jc.2018-02318

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    2019-11-11 smallant2015
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    2019-05-20 achengzhao
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