J Periodontal Res:慢性牙周炎患者龈沟液中人β-防御素-1水平的变化

2018-10-01 MedSci MedSci原创

人β-防御素(hBD)有助于先天免疫抗菌活性。它们在适应性免疫应答中也是有效的,并且可能在对口腔疾病的易感性中起关键作用。本研究旨在评估患和不患慢性牙周炎的个体的龈沟液中hBD-1的水平。

人β-防御素(hBD)有助于先天免疫抗菌活性。它们在适应性免疫应答中也是有效的,并且可能在对口腔疾病的易感性中起关键作用。本研究旨在评估患和不患慢性牙周炎的个体的龈沟液中hBD-1的水平。

方法:研究中招募了20个牙周健康个体(H)和20个患有慢性牙周炎的个体。从牙周健康个体的健康位点(Hh)收集龈沟液样本;从牙周炎患者的健康位点(Ph),牙龈炎(Pg)位点和牙周炎(Pp)位点收集样本。使用酶联免疫吸附测定法测量hBD-1(pg / mL)的水平。通过分层线性建模进行个体(H和慢性牙周炎)和位点(Hh,Ph,Pg,Pp)之间hBD-1的比较。

结果:hBD-1的龈沟液水平为:Hh = 229.52±138.96(中位数199.26),Ph = 53.88±58.17(中位数35.75),Pg = 57.11±40.18(中位数39.90),Pp = 55.31±37.28(中位数54.19)。未观察到位点诊断(1级;健康/牙龈炎/牙周炎)的影响;然而,个体诊断(2级;健康/牙周炎)影响hBD-1水平(P <.001)。

与患有慢性牙周炎的个体相比,牙周健康个体龈沟液hBD-1水平更高。这表明hBD-1在慢性牙周炎易感性中具有潜在的保护作用。

原始出处:

L. C. M. Costa, et al.Gingival crevicular fluid levels of human beta‐defensin 1 in individuals with and without chronic periodontitis. Journal of  Periodontal Research. 2018 October. Doi:10.1111/jre.12558

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    2019-08-02 feather89
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    2018-10-06 wxl882001

    学习一下

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