Radiology:高、低级别星形细胞瘤的鉴别

2018-02-27 shaosai MedSci原创

目的:评价由动态磁敏感增强(DSC)MR成像产生的动脉输入函数(AIFs)或AIFDSC值在鉴别低、高级胶质瘤时,能否改善动态对比(DCE)MR成像药物动力学参数(PK)的诊断准确性和可靠性,并与DCE MR成像所获得的AIF进行比较(AIF DCE)。

目的:评价由动态磁敏感增强(DSC)MR成像产生的动脉输入函数(AIFs)或AIFDSC值在鉴别低、高级胶质瘤时,能否改善动态对比(DCE)MR成像药物动力学参数(PK)的诊断准确性和可靠性,并与DCE MR成像所获得的AIF进行比较(AIF DCE)。

材料与方法:本次回顾性研究共纳入226例经病理证实胶质瘤(世界卫生组织分级,Ⅱ级=21,Ⅲ级=53,Ⅳ级=152;异柠檬酸脱氢酶突变体,11.95%(27/226);1p19qco缺失0%[0/226])患者(男138例,女88例;平均年龄52.27岁±15.17岁;范围:24-84岁)。所有病人术前均行DSC及DCE MR检查,获取每一幅图像的AIF DSC 和 AIF DCE。用后处理软件处理两组AIFs的容积转移常数(K trans),血管等离子空间体积(Vp),血管外间隙容积(Ve)。用受试者特性曲线(ROC)分析比较各参数的诊断准确性。采用组内相关系数(ICCs)和Bland-Altman方法进行评估可靠性。

结果:AIFDSC的K trans和v e 值比AIFDCE在鉴别低、高级胶质瘤时更准确(ROC曲线下面积:平均 K trans,0.796vs.0.995; v p,0.848 vs 0.728; v e,0.875 vs 0.581),相关性比较中,这三个参数AIF DSC优于AIFDCE要好(K trans, 0.737 vs 0.095; v p, 0.848 vs 0.728; v e, 0.875 vs 0.581)。在AIF分析中,AIF DSC 在最大信号强度(0.837 vs 0.524),斜率(0.800 vs 0.432)相关性比较中优于 AIF DCE。

结论:DCE MR成像药物动力学参数产生的AIF DSC优于AIF DCE在鉴别低、中胶质瘤时有较好的诊断准确性和可靠性。

原始出处:

You SH, Choi SH, Kim TM. et al.Differentiation of High-Grade from Low-Grade Astrocytoma: Improvement in Diagnostic Accuracy and Reliability of Pharmacokinetic Parameters from DCE MR Imaging by Using Arterial Input Functions Obtained from DSC MR Imaging.Radiology.DOI: 10.1148/radiol.2017170764

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    2018-03-04 大爰

    学习了谢谢分享!!

    0

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    2018-02-28 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-02-28 yfjms

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=292831, encodeId=e84f292831e6, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Mar 04 08:20:38 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475888, encodeId=a17314e58888c, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Thu Mar 01 13:04:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291733, encodeId=33ad291e33d3, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Feb 28 16:08:35 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291642, encodeId=83bc29164268, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed Feb 28 08:32:40 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291524, encodeId=543329152435, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Feb 28 01:26:37 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291491, encodeId=1bbd291491ae, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Feb 27 23:07:57 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291480, encodeId=3a89291480c0, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Feb 27 22:21:21 CST 2018, time=2018-02-27, status=1, ipAttribution=)]
    2018-02-28 三生有幸9135

    学习一下谢谢分享

    0

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    2018-02-27 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

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    2018-02-27 王秀

    学习了.涨知识了!

    0

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