Diabetic Med:1型糖尿病孕妇体重增加所导致的长孕期新生儿发病率较高

2019-04-01 不详 网络

<span style="font-size:9.0pt;font-family:宋体;mso-ascii-theme-font:major-fareast; mso-fareast-theme-font:major-fareast;mso-hansi-theme-font:major-fareast; color:black;mso-bidi-font-weight:bold">近日,国际杂

近日,国际杂志 《Diabetic Med》上在线发表一项关于1糖尿病孕妇体重增加所导致的长孕期新生儿发病率较高以及比较使用连续皮下胰岛素输注与多剂量胰岛素注射的研究。

比较通过连续皮下注射胰岛素,每日多次注射胰岛素或从妊娠早期连续皮下注射胰岛素(MDI)转为连续皮下胰岛素输注(CSII)的妊娠期1糖尿病患者的血糖控制,孕产妇和新生儿结局。

研究回顾性分析了339例单胎妊娠的数据。在孕前和每个妊娠期测量HbA1c值。在二级分析中,将孕前CSII的使用与怀孕期间CSII的启动进行比较。

研究显示MDI用于140例妊娠(41.3%),CSII用于199例(58.7%),包括转为CSII 34例妊娠(10.0%)。在使用CSII糖尿病病程期间, 妊娠时间[中位数(四分位数间距)16.08.0-23.0)年与11.05.5-17.5)年; P <0.001]更长,并且医学研究所建议的适当增加体重被更频繁地超过(64.8%对50.8; P = 0.01)。CSII使用和孕前BMI是体重过度增加的独立预测因子。血糖控制没有差异,但比MDI比较,CSII与较高的出生体重 [中位数(四分位数间距)37203365-4100g vs 33603365-4100g; P <0.001]和更大的孕龄(LGA)率(44.7%对33.6;P = 0.04)有关。妊娠晚期HbA 1c浓度和体重增加过多可预测LGA婴儿[比值比2.3395CI 1.54-3.51; P <0.0011.8995CI 1.02-3.51; P = 0.04]。在妊娠早期和孕前使用CSII治疗的妊娠中,实现了类似的血糖控制和结果。

研究表明,CSII在血糖控制和新生儿结局方面没有优势。CSIILGA新生儿的发病率较高,可能是由于母亲体重增加过多引起的,这比接受MDI治疗的女性更为频繁。

原始出处:

F. HauffeU. M. SchaeferGrafR. Fauzanet al. Higher rates of largeforgestationalage newborns mediated by excess maternal weight gain in pregnancies with Type 1 diabetes and use of continuous subcutaneous insulin infusion vs multiple dose insulin injection

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    2019-05-15 一天没事干

    很好的学习机会

    0

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    2019-04-02 misszhang

    谢谢MedSci提供最新的资讯

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