Korean J Intern Med:类风湿性关节炎患者中重度牙周炎的发病率较高

2016-03-30 MedSci MedSci原创

本次横断面研究旨在探究牙周炎的严重程度和类风湿性关节炎的临床表现之间的关联。 研究共纳入了264名类风湿性关节炎患者和88名匹配了年龄和性别对照人群,对所有研究对象进行牙科检查。此外,还要评估类风湿性关节炎患者的临床表现,包括疾病活动性和抗环瓜氨酸肽抗体。

本次横断面研究旨在探究牙周炎的严重程度和类风湿性关节炎的临床表现之间的关联。

研究共纳入了264名类风湿性关节炎患者和88名匹配了年龄和性别对照人群,对所有研究对象进行牙科检查。此外,还要评估类风湿性关节炎患者的临床表现,包括疾病活动性和抗环瓜氨酸肽抗体。

与对照人群相比,类风湿性关节炎患者的中度或重度牙周炎的患病率较高。在牙周炎症标志物中,探诊出血与疾病活动评分28、类风湿性关节炎病程、红细胞沉降率、抗环瓜氨酸肽抗体和抗环瓜氨酸肽抗体α烯醇化酶肽-1抗体相关。牙龈指数与类风湿性关节炎的病程、ESR、抗环瓜氨酸肽抗体和抗环瓜氨酸肽抗体α烯醇化酶肽-1抗体相关。与没有共同抗原表位的患者相比,存在人类白细胞抗原(HLA)-DRB1共同表位的类风湿性关节炎患者,其牙周探诊深度和临床附着水平代表的牙周结构损伤的程度较低。

总而言之,与对照组人群相比,类风湿性关节患者的中度或重度牙周炎患病率较高。牙周组织炎症与类风湿性关节炎的病程、ESR及抗环瓜氨酸肽抗体有关。存在HLA-DRB1共同抗原表位的类风湿性关节患者的牙周组织结构破坏较小。

原始出处:

Choi IA, Kim JH, Kim YM, Lee JY, Kim KH, Lee EY, Lee EB, Lee YM, Song YW. Periodontitis is associated with rheumatoid arthritis: a study with longstanding rheumatoid arthritis patients in Korea. Korean J Intern Med. 2016 Mar 25. doi: 10.3904/kjim.2015.202.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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createdTime=Fri Apr 01 12:43:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483396, encodeId=6e501483396e0, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Apr 01 12:43:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606882, encodeId=ef941606882de, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 01 12:43:00 CST 2016, time=2016-04-01, status=1, ipAttribution=)]
    2016-09-12 ylzr123

    赞!深度好文。

    0

  5. 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createdTime=Fri Apr 01 12:43:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483396, encodeId=6e501483396e0, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Apr 01 12:43:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606882, encodeId=ef941606882de, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 01 12:43:00 CST 2016, time=2016-04-01, status=1, ipAttribution=)]
    2016-04-01 lmm397
  6. 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