eLife:男性个子越高,患痴呆症的风险越低

2020-02-15 小通 生物通

即使将教育程度和智力水平考虑进去,这种关联仍然存在。

即使将教育程度和智力水平考虑进去,这种关联仍然存在。

随着全球人口老龄化,痴呆症已经是一个严重的问题。据世卫组织统计,每年有近1000万人患痴呆症。了解哪些个体的痴呆症风险较高,这一点至关重要,有助于人们采取预防措施。近日一项发表在《eLife》上的研究表明,个子较高的男性在年老时罹患痴呆症的风险较低。

先前的研究表明,身高可能是痴呆症的风险因素,但是许多研究都没有考虑到可能与身高和痴呆症相关的遗传、环境及其他早期生活因素。于是,丹麦的研究人员希望探索两者的关联以及智力水平、教育程度、早期生活环境和家庭因素的影响。

通讯作者、哥本哈根大学的助理教授Terese Sara H?j J?rgensen表示:“我们想了解年轻人的身高是否与痴呆症的诊断有关,同时探讨兄弟俩的智力测验分数、教育水平和潜在的环境和遗传因素是否能够解释这种关系。”

J?rgensen及其同事分析了1939年至1959年之间出生的666,333名丹麦男性的数据,包括70,608名兄弟和7,388名双胞胎。他们发现,总共有10,599名男性在年老时患上痴呆症。

他们调整分析后表明,对于平均身高以上的男性,身高每增加6 cm,患痴呆症的风险降低10%。当研究团队考虑到智力或教育的潜在作用时,身高与痴呆症风险之间的关联仅仅略微降低。

研究人员发现,在他们研究身高不同的兄弟时,身高和痴呆症风险之间的关联同样存在,这表明遗传和家庭因素本身并不能解释为什么矮个子的男性患痴呆症的风险更大。当他们研究双胞胎的数据时也是如此,不过该组的结果尚不确定。

资深作者、哥本哈根大学的教授Merete Osler解释说:“我们研究的主要优势在于,它针对教育和智力在年轻男性痴呆症风险中的潜在作用进行了调整。教育和智力这两个因素有可能帮助人们建立认知储备,使得这一群体不容易患上痴呆症。” 所谓“认知储备”,指的是大脑即兴发挥并解决日常生活中问题的能力。

Osler表示:“总的来说,我们的结果表明,年轻男性的身高较高与年老后的痴呆症风险较低存在关联,即使我们对教育程度和智力水平进行调整,这种关联仍然存在。关于兄弟的分析证实了这一点,表明这种关联可能源于早期环境暴露,而与家庭因素无关。”

她补充说,这项研究的一个限制在于尚不确定这些结论是否可以推广到女性。之前也有一些研究是分析身高与痴呆症的关系是否存在性别差异,但大多没有定论。

原始出处:
  • Terese Sara Høj Jørgensen 
  • Gunhild Tidemann Okholm 
  • Kaare Christensen 
  •  et al. Body height in young adult men and risk of dementia later in adult life. eLife. Feb 11, 2020

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      2020-07-24 膀胱癌
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      2020-04-08 clmlylxy
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      2020-08-25 Boyinsh
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      2020-02-15 thm112988

      0

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      2020-02-15 junJUN

      老年人痴呆何药可用??

      0

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