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CLIN CANCER RES：Taselisib联合Fulvestrant治疗晚期乳腺癌

2018-09-19 MedSci MedSci原创

晚期乳腺癌Taselisibfulvestrant
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CLIN CANCER RES近期发表了一篇文章，报道了Taselisib联合Fulvestrant治疗局部晚期或转移性HER2阴性，激素受体阳性绝经后乳腺癌患者的Ⅱ期临床试验结果。

CLIN CANCER RES近期发表了一篇文章，报道了Taselisib联合Fulvestrant治疗局部晚期或转移性HER2阴性，激素受体阳性绝经后乳腺癌患者的Ⅱ期临床试验结果。

患者口服Taselisib 6mg每天联合肌内注射Fulvestrant（500mg）直至出现疾病进展或不可耐受毒性。分析肿瘤组织PIK3CA突变情况。使用NCICTCAE v4.0记录不良反应。使用RECIST v1.1评估肿瘤反应。研究结果表明，中位治疗持续时间为4.6个月。所有患者均出现≥1级不良反应，30例患者出现≥3级不良反应，19例患者出现35种严重不良反应。47例患者的肿瘤组织可以进行PIK3CA突变评估（20例存在突变，27例未检测到突变）。PIK3CA突变患者最佳确认缓解率为38.5%，临床获益率为38.5%。PIK3CA-MND患者最佳确认缓解率为14.3%，临床获益率为23.8%，PIK3CA突变状态未知的患者最佳确认缓解率为20.0%，临床获益率为30.0%。

文章最后认为，Taselisib联合Fulvestrant治疗HER2阴性，激素受体阳性局部晚期或转移性乳腺癌患者具有临床活性，且与PIK3CA突变状态无关。未发现新的安全问题，目前正在进行Ⅲ期临床试验。

原始出处：
Maura N.Dickler,Cristina Saura,et al.Phase ⅡStudy of Taselisib(GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative,Hormone Receptor-Positive Advanced Breast Cancer.CLIN CANCER RES.September 2018 doi:10.11558/1078-0432.CCR-18-0613

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    2018-11-02 xiangyuzhou971

    #EST#

    0

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    2019-05-31 bsmagic9140

    #TRA#

    0

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    2019-09-01 xqptu

    #fulvestrant#

    0

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    2019-06-18 qingting

    #Taselisib#

    0

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    2018-09-19 天地飞扬

    了解一下，谢谢分享！

    0

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    2018-09-19 医者仁心5538

    学习了

    0

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