J Med Virol:重症腺病毒性肺炎患儿闭塞性细支气管炎发展的危险因素

2020-02-20 不详 网络

本研究旨在调查和分析重症腺病毒性肺炎患儿闭塞性细支气管炎(BO)的相关危险因素。重庆医科大学附属儿童医院2015年1月至2019年2月,对重度腺病毒性肺炎患儿34例发展为BO和105例未发展为BO的患儿进行回顾性研究。多因素logistic回归分析确定了显着性因素。进行单因素分析后,与BO的发展相关联,并进行受试者工作特征(ROC)曲线分析以找出重要相关因素的临界值。通过限制性三次样条模型评估了危

本研究旨在调查和分析重症腺病毒性肺炎患儿闭塞性细支气管炎(BO)的相关危险因素。

重庆医科大学附属儿童医院2015年1月至2019年2月,对重度腺病毒性肺炎患儿34例发展为BO和105例未发展为BO的患儿进行回顾性研究。多因素logistic回归分析确定了显着性因素。进行单因素分析后,与BO的发展相关联,并进行受试者工作特征(ROC)曲线分析以找出重要相关因素的临界值。通过限制性三次样条模型评估了危险因素与BO风险之间的非线性剂量反应关系。

结果显示,发烧时间长(OR 1.129,95%CI 1.033-1.234),呼吸困难(OR 3.922,95%CI 1.060-14.514)和有创机械通气(OR 6.861,95%CI)三个因素与BO的发生独立相关。 1.854-25.387)。发烧时间的临界值为10.5天。观察到发烧时间与BO的发生之间存在线性的剂量反应关系(非线性度p = 0.57)。

综上所述,该研究结果表明,重度腺病毒性肺炎的发烧时间较长(特别是超过10.5天),呼吸困难或在急性期需要有创机械通气的儿童更容易发生BO。

原始出处:

Zhong L, Lin J, Dai J. Risk factors for the development of bronchiolitis obliterans in children with severe adenovirus pneumonia: A retrospective study with dose-response analysis. J Med Virol. 2020 Feb 18. doi: 10.1002/jmv.25703.

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    2020-04-13 howi
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