Evolution:禁食疗法弊端再添新证据

2014-07-21 佚名 生物谷

纵观历史,人们一直在寻找长生不老之法,不管是从饮食还是服用维生素药片上,人们尝试了很多种方法;如今,来自英国巴斯大学的研究人员通过研究表示,抗老化疗法比如服用抗氧化剂或限制饮食等仅对抗衰老具有短暂的效应,而且其也存在一定的风险,相关研究刊登于国际杂志Evolution上。近年来,一种名为间歇性禁食(Intermittent Fasting)或者5:2饮食的一种策略广为流行,名人和媒体都认为这种饮食

纵观历史,人们一直在寻找长生不老之法,不管是从饮食还是服用维生素药片上,人们尝试了很多种方法;如今,来自英国巴斯大学的研究人员通过研究表示,抗老化疗法比如服用抗氧化剂或限制饮食等仅对抗衰老具有短暂的效应,而且其也存在一定的风险,相关研究刊登于国际杂志Evolution上。[pdf free]

近年来,一种名为间歇性禁食(Intermittent Fasting)或者5:2饮食的一种策略广为流行,名人和媒体都认为这种饮食方式可以降低血压、增加机体寿命以及保护机体抵御各种疾病,比如痴呆症等。

然而本文中,研究者认为这样的饮食方式或许会长期影响机体的免疫系统,使得人们对感染更加敏感;研究者在果蝇机体中研究了4种压力和免疫相关的基因,这几个基因被认为与长寿相关,并且可以帮助理解预期寿命和抵御感染能力之间的关系,相似的基因也会被抗老化疗法(比如绝食疗法或服用抗氧化剂)激活。



研究者表示,通过暴露于真菌感染的方式,果蝇机体的压力和免疫基因被激活,果蝇寿命明显延长;然而从长期效果来讲,这种延长果蝇寿命的疗法或许会引发果蝇机体免疫系统功能的明显下降,使其更容易感染。本文中研究的果蝇基因和人类中的基因类似,因此研究者认为在果蝇机体的表现同样也适用于人类机体。

研究者Nick Priest博士表示,许多研究都揭示了限制饮食和抗氧化剂服用的益处,但是目前缺少抗老化疗法对人类疾病水平影响的数据;我们都知道特定的压力比如饥饿或者暴露于致病菌中都会延长机体寿命、增加繁殖力,但是我们也发现长期以来这种方式会明显降低免疫系统的活性。在老年晚期癌症患者中短期禁食或许可以增加机体白细胞水平并且帮助患者抵御癌症,这就表明急性禁食或许是具有有益效应的。

未来研究者们还将通过对果蝇模型进行深入研究来揭示高蛋白饮食,比如阿特金斯饮食法是否会增加果蝇机体的免疫系统功能。

原始出处:

McClure CD1, Zhong W, Hunt VL, Chapman FM, Hill FV, Priest NK.HORMESIS RESULTS IN TRADE-OFFS WITH IMMUNITY.Evolution. 2014 May 26. doi: 10.1111/evo.12453. [pdf free]

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    2016-09-04 1e0d037em49(暂无匿称)

    学习了有用。

    0

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    2014-09-24 xugumin
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    2015-06-28 yese
  5. [GetPortalCommentsPageByObjectIdResponse(id=110686, encodeId=0136110686be, content=学习了有用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf931932042, createdName=1e0d037em49(暂无匿称), createdTime=Sun Sep 04 09:17:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005973, encodeId=5c8320059e3ed, content=<a href='/topic/show?id=5d53e12740' target=_blank style='color:#2F92EE;'>#Evolution#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7127, encryptionId=5d53e12740, topicName=Evolution)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sat Oct 11 09:47:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694399, encodeId=a6441694399a8, content=<a href='/topic/show?id=988b101054d0' target=_blank style='color:#2F92EE;'>#食疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101054, encryptionId=988b101054d0, topicName=食疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Wed Sep 24 14:47:00 CST 2014, time=2014-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785883, encodeId=8c241e858836e, content=<a href='/topic/show?id=d12fe126c4' target=_blank style='color:#2F92EE;'>#Evolut#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7126, encryptionId=d12fe126c4, topicName=Evolut)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sun Jun 28 20:47:00 CST 2015, time=2015-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10566, encodeId=c5b710566e8, content=为什么不注明作者?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=123.139.204.216, createdTime=Tue Jul 22 00:05:00 CST 2014, time=2014-07-22, status=1, ipAttribution=)]
    2014-07-22 123.139.204.216

    为什么不注明作者?

    0

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