JCLA:绝经后梅尼埃病患者听觉前庭功能与雌激素水平的关系

2019-05-16 不详 网络

目的探讨绝经后女性梅尼埃病(MD)患者的听觉和前庭功能、雌激素水平及其临床相关性。

目的探讨绝经后女性梅尼埃病(MD)患者的听觉和前庭功能、雌激素水平及其临床相关性。

研究人员回顾性分析了血清雌二醇(E2)水平和听力和前庭功能以听觉脑干反应(ABR)高点击率,纯量语气听力测定(PTA)和热量测试在绝经后妇女患有医学专科诊所的眩晕。

本研究共纳入76例绝经后MD患者和50例健康绝经后对照者。MD患者雌激素水平较低(22.50±16.66 pg/mL vs 30.69±18.59 pg/mL, P = 0.011) ABR IV间期较长(0.22±0.16 mseconds vs 0.18±0.10 mseconds, P = 0.118;0.24±0.13 mseconds vs . 0.17±0.09 mseconds, P = 0.001),单侧乏力(UW)值高于对照组(P < 0.001)MD患者的平均纯音阈值(500 Hz1 kHz2 kHz3 kHz)显著高于对照组(P < 0.001,右P < 0.01)MD患者雌二醇水平与ABR潜伏期相关(r = - 0.229, P < 0.05;r = - 0.220, P < 0.05)UW(r = - 0.328, P < 0.05),但不含平均纯‐音调阈值。

研究表明,绝经后MD患者的雌激素水平与听觉和前庭功能相关,低雌激素可能参与内耳微循环紊乱,影响MD的发生发展。

原始出处:

Huirong Jian,  Gang Yu ,Correlation between auditoryvestibular functions and estrogen levels in postmenopausal patients with Meniere's disease

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