Sci Rep:心脏康复期间心脏移植和左心室辅助装置植入患者之间生化标志物的差异

2018-07-18 xiangting MedSci原创

在康复期间,应注意HTx患者早期出现的血脂异常和高血糖,这需要适当的蛋白质膳食支持。LVAD患者中很低的IGF-1可能导致患者的康复预后差。

心脏移植(HTx)和左心室辅助装置(LVAD)植入是症状性终末期心衰的最佳选择,但LVAD患者的康复预后不如HTx患者。

为了调查原因,研究人员比较了进入同一心脏康复计划的51名HTx患者和46名LVAD患者的生物标志物水平及其与康复结局的关联。两组在心脏康复的开始(T1)和结束(T2)检测常规生物标志物,而仅在T1检测同型半胱氨酸、瘦素和IGF-1。

HTx患者T1时的淋巴细胞、血小板、葡萄糖、总蛋白和白蛋白较低;当在HTx中观察到新的糖尿病病例时,康复期间与LVAD患者的差异消失。与之相反,HTx患者的总胆固醇、LDL和HDL分数、瘦素和IGF-1较高。从T1到T2六分钟步行试验距离的增加、功能性康复结局的指标与HTx患者的同型半胱氨酸和IGF-1水平呈正相关。

总之,在康复期间,应注意HTx患者早期出现的血脂异常和高血糖,这需要适当的蛋白质膳食支持。LVAD患者中很低的IGF-1可能导致患者的康复预后差。

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    2018-07-20 jiyangfei
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    2018-07-19 mswert122

    **

    0

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    2018-07-18 lietome2

    好文值得点赞认真学习应用于实践谢谢分享给广大同好

    0

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