Carbohydr Polym:壳聚糖-氧化石墨烯,毒性小,抗菌好

2019-09-25 不详 网络

本研究旨在找到一种方法来提高氧化石墨烯(GO)纳米粒子的生物适用性。通过将不同种类的壳聚糖(CS)结构与GO相连,合成了各种氧化石墨烯-壳聚糖(GO-CS)纳米杂化物。随后,根据结构特征,抗菌活性和细胞毒性对它们进行了评估,以获得代表最高杀菌和生物相容性性能的杂化结构。结果表明,研究人员成功地合成了单层GO以及三种不同类型的GO-CS纳米杂化结构(原始粉末,球形和纳米纤维网络结构)。抗菌活性结果表

本研究旨在找到一种方法来提高氧化石墨烯(GO)纳米粒子的生物适用性。

通过将不同种类的壳聚糖(CS)结构与GO相连,合成了各种氧化石墨烯-壳聚糖(GO-CS)纳米杂化物。随后,根据结构特征,抗菌活性和细胞毒性对它们进行了评估,以获得代表最高杀菌和生物相容性性能的杂化结构。

结果表明,研究人员成功地合成了单层GO以及三种不同类型的GO-CS纳米杂化结构(原始粉末,球形和纳米纤维网络结构)。抗菌活性结果表明,与纯GO相比,纳米杂化物具有更好的抗菌活性。另外,观察到CS附着到GO上降低了GO的细胞毒性作用,甚至在一些样品中可促进细胞增殖。

此外,研究人员比较了不同纳米杂化物的抗菌和生物安全性,并提出了其特殊性能的潜在机制。

原始出处:

Joz Majidi H, Babaei A, et al., Investigating the best strategy to diminish the toxicity and enhance the antibacterial activity of graphene oxide by chitosan addition. Carbohydr Polym. 2019 Dec 1;225:115220. doi: 10.1016/j.carbpol.2019.115220. Epub 2019 Aug 20.

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