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Diabetes Care：DPP-IV 活性与2型糖尿病患者轻度认知障碍的发生独立相关

2016-07-06 MedSci MedSci原创

DPP-IV2型糖尿病轻度认知障碍
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既往研究表明高血糖、炎症和氧化应激参与了机体认知功能减退的发病机制。二肽基肽酶-4（DPP-4）是新发现的一种脂肪细胞因子，与这些危险因素相关。因此，本研究旨在探讨老年2型糖尿病患者血浆DPP-4活性和轻度认知障碍（MCI）之间的关联。研究共纳入了1160名2型糖尿病患者，年龄≥60岁，评估其血浆DPP-4的活性，炎症标志物及氧化应激指标。基于美国国立老龄研究院-阿尔茨海默病协会工作组制定的标准诊

既往研究表明高血糖、炎症和氧化应激参与了机体认知功能减退的发病机制。二肽基肽酶-4（DPP-4）是新发现的一种脂肪细胞因子，与这些危险因素相关。因此，本研究旨在探讨老年2型糖尿病患者血浆DPP-4活性和轻度认知障碍（MCI）之间的关联。

研究共纳入了1160名2型糖尿病患者，年龄≥60岁，评估其血浆DPP-4的活性，炎症标志物及氧化应激指标。基于美国国立老龄研究院-阿尔茨海默病协会工作组制定的标准诊断MCI。

结果发现，与DPP-4活性四分位数最低的患者相比，DPP-4活性四分位数最高的患者糖化血红蛋白、白细胞介素6（IL-6）、CRP、硝基酪氨酸及8-iso-PGF2a的水平较高，而蒙特利尔认知评估量表（MoCA）的评分较低（P＜0.001）。校正混杂因素后，与DPP-4活性四分位数最低的患者相比，DPP-4活性四分位数最高的患者其MCI的发生风险较高（OR，3.49；95% CI 1.97–4.57）。DPP-4活性，IL-6、CRP、硝基酪氨酸和8-iso-PGF2a的水平越高，MCI的发生风险增加越高（P＜0.05），但是与高水平的糖化血红蛋白则无此关系。

总而言之，该研究表明， DPP-4活动增加与老年2型糖尿病患者MCI的发生独立相关。其部分机制或是由于DPP-4在炎症和氧化应激中发挥作用的原因。DDP-4活性对MCI相关的危险因素的作用使其具备成为MCI发生的生物标记物的潜力，甚至是成为MCI治疗的一个潜在的靶点。

原始出处：

Tianpeng Zheng, Linyuan Qin, Bo Chen, Xueping Hu, Xiaoxi Zhang, Yihong Liu, Hongbo Liu, ShenghuaQin, Gang Li, Qinghua Li. Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China. Diabetes Care 2016 Jul; dc160316. http://dx.doi.org/10.2337/dc16-0316.


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    2017-03-12 木头人513

    #Diabetes#

    0

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    2016-11-20 ms5439512287675881

    #BET#

    0

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    2016-10-11 ylzr123

    赞了，认真探究、学习。

    0

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    2017-01-12 ms9608593228839890

    #DIA#

    0

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    2016-07-08 aids213

    #2型糖尿病患者#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1901407, encodeId=9281190140ef5, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Mar 12 20:45:00 CST 2017, time=2017-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759704, encodeId=21201e5970403, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Nov 20 04:45:00 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145876, encodeId=88e41458e6ed, content=赞了，认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 22:20:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637386, encodeId=ef35163e3863d, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Jan 12 01:45:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383231, encodeId=ea7f1383231b5, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jul 08 08:45:00 CST 2016, time=2016-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474011, encodeId=9f4414e4011d7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jul 08 08:45:00 CST 2016, time=2016-07-08, status=1, ipAttribution=)]
    2016-07-08 xue8604

    #糖尿病患者#

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