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2019年神经肿瘤学会：IL-12治疗复发性胶质母细胞瘤的临床数据

2019-11-25 Allan MedSci原创

IL-12神经肿瘤学会胶质母细胞瘤
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Ziopharm制药公司近日宣布，其IL-12作为单一疗法或与PD-1抑制剂联合用于治疗成人复发性或进行性多形胶质母细胞瘤（rGBM）时取得突破性进展，其最新结果将在在2019年神经肿瘤学会（SNO）年会上发表。

Ziopharm制药公司近日宣布，其IL-12作为单一疗法或与PD-1抑制剂联合用于治疗成人复发性或进行性多形胶质母细胞瘤（rGBM）时取得突破性进展，其最新结果将在在2019年神经肿瘤学会（SNO）年会上发表。Ziopharm首席执行官Laurence Cooper博士说：“复发性GBM是一种复杂的疾病，其自身会脱离免疫系统而生长。将IL-12置于肿瘤中，然后控制这种细胞因子的产生，会促使T细胞进入肿瘤，从而使适应性免疫系统具有抗肿瘤活性。我们对这项研究的结果感到鼓舞”。

胶质母细胞瘤是星形细胞肿瘤中恶性程度最高的胶质瘤。肿瘤位于皮质下，多数生长于幕上大脑半球各处。呈浸润性生长，常侵犯几个脑叶，并侵犯深部结构，还可经胼胝体波及对侧大脑半球。 


原始出处：

http://www.firstwordpharma.com/node/1683112#axzz66FB9zUrI

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    2019-12-25 30397604

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    2020-10-21 chenlianhui

    #临床数据#

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    2020-02-23 huperzia

    #母细胞瘤#

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encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Feb 13 12:57:00 CST 2020, time=2020-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083551, encodeId=ea492083551aa, content=<a href='/topic/show?id=2374e451215' target=_blank style='color:#2F92EE;'>#神经肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74512, encryptionId=2374e451215, topicName=神经肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e03212, createdName=liao1619, createdTime=Thu Sep 10 03:57:00 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978153, encodeId=0fef19e815312, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Jan 09 10:57:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390795, encodeId=15891390e95c9, content=<a href='/topic/show?id=8eeb828963a' target=_blank style='color:#2F92EE;'>#肿瘤学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82896, encryptionId=8eeb828963a, topicName=肿瘤学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476039, encodeId=54b314e603963, content=<a 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2020-02-13 hb2008ye

    #复发性#

    0

  5. 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href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508258, encodeId=d6861508258a5, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2020-09-10 liao1619

    #神经肿瘤#

    0

  6. 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level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Jan 09 10:57:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390795, encodeId=15891390e95c9, content=<a href='/topic/show?id=8eeb828963a' target=_blank style='color:#2F92EE;'>#肿瘤学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82896, encryptionId=8eeb828963a, topicName=肿瘤学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476039, encodeId=54b314e603963, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508258, encodeId=d6861508258a5, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2020-01-09 仁者大医

    #IL-12#

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-26 108807375_62823127

    #肿瘤学#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-26 spoonycyy

    #细胞瘤#

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-26 jjjiang0202

    #IL-1#

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537088, encodeId=cf18153e088d8, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Tue Nov 26 23:57:00 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-26 charl1234571

    #复发性胶质母细胞瘤#

    0

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阻断IL-12和IL-23可以有效的缓解白细胞粘附缺陷1型症状

SCI REP：白介素-12A rs568408与台湾哮喘易感性的关系

哮喘是一种炎性疾病，也是最常见的慢性呼吸道疾病，病症相对比较复杂，白细胞介素12（IL-12）可能在过敏原诱导的炎症中起调节作用。本研究的目的就是研究IL-12A / IL-12B的多态性与哮喘的关系。

复发胶质母细胞瘤治疗的新近进展

Ziopharm Oncology公司近日宣布开始进行II期临床试验，以评估基因疗法（IL-12受控表达系统）与PD-1抗体Libtayo联合用于成人复发性或进行性胶质母细胞瘤（rGBM）的有效性和安全性。多中心试验将在美国约10家专门治疗脑癌的医院进行。

J Periodontol：牙周膜细胞中IL-12诱导核因子κB受体活化因子配体表达

促炎细胞因子白细胞介素（IL）-12的水平升高与牙周炎的严重程度相关。 然而，IL-12在牙周病中可能的作用还不清楚。 这项研究的目的是调查IL-12是否影响人类牙周膜（hPDL）细胞的核因子κB（NF-κB）配体（RANKL）的受体激活剂的表达，RANKL是一种有效的破骨细胞刺激因子。

Biosci Rep：IL-12介导的人牙周膜细胞MMPs的表达涉及NF-κB的活化

白介素（IL-12）是一种促炎细胞因子，其水平的增加与牙周炎的严重程度相关。然而，IL-12在牙周病变发病机制中的作用是有争议的，目前尚未得到充分的阐明。本研究旨在研究IL-12是否影响人牙周膜成纤维细胞（hPDLFs）中基质金属蛋白酶（MMPs）和金属蛋白酶组织抑制剂（TIMP）的表达。使用IL-12处理hPDLFs不同时间后，分别采用实时荧光定量PCR和蛋白质印迹法检测MMP-1，MMP-2，