Brit J Cancer:II/III期结肠癌患者边侧性、分子亚型及治疗响应

2018-01-15 zhangfan MedSci原创

研究认为,对于III期结肠癌患者,左侧肿瘤患者总生存期延长,但对于无复发生存期和奥沙利铂治疗收益的影响不显著。肿瘤分子亚型对奥沙利铂治疗收益的预测效果优于肿瘤边侧性

近日研究人员考察了II-III期结肠癌患者肿瘤边侧性与预后、分子亚型及奥沙利铂治疗敏感性之间的关系。

NSABP/NRG C-07研究包含1603名患者,考察了患者结肠癌边侧性与分子亚型、无复发生存期(RFS)以及总生存期(OS)之间的关系。

研究发现,除茎样/CMS4亚型外,边侧性与亚型相关。对于III期,左侧肿瘤患者,其总生存期延长,但对无复发生存期无显著影响。当奥沙利铂、5氟尿嘧啶与醛氢叶酸联用时,边侧性与治疗收益无关,但对于III期左侧上皮型肿瘤患者,奥沙利铂治疗的收益显著(HR=0.17, P=0.01)。

研究认为,对于III期结肠癌患者,左侧肿瘤患者总生存期延长,但对于无复发生存期和奥沙利铂治疗收益的影响不显著。肿瘤分子亚型对奥沙利铂治疗收益的预测效果优于肿瘤边侧性。

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    2018-03-25 juliusluan78
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    2018-02-05 方舒

    学习

    0

  3. 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    2018-01-26 大爰

    学习了谢谢分享!!

    0

  4. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jan 17 07:12:10 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339934, encodeId=8fbf1339934c3, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=279050, encodeId=855f2e905071, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 16 11:17:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-20 方舒

    学习

    0

  5. 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    2018-01-19 jyzxjiangqin

    结肠癌的治疗.

    0

  6. 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    2018-01-17 大爰

    学习了谢谢分享!!

    0

  7. 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    2018-01-16 thlabcde

    好资料学习了!

    0

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    2018-01-16 神功盖世

    0

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JAMA Oncology:术前和术后CEA水平与结肠癌预后的关系

临床指南建议检测结肠癌术前CEA水平。术后CEA水平持续升高与肿瘤转移风险增加有关,但是术前升高术后正常的CEA水平的预后作用尚不清楚。JAMA Oncology近期发表了一篇文章,研究术前CEA水平高,术后降至正常的患者是否比术前CEA水平正常的患者复发风险更高。

Brit J Cancer:骨髓间充质细胞在低剂量辐射下可促进大肠癌细胞死亡

研究认为,骨髓间充质干细胞可强化结肠癌的放疗效果

Gastroenterology:非恶性肠道息肉手术率呈上升趋势

研究发现,在过去14年间,非恶性肠道息肉切除术得到普及且手术率显著增加

JAMA Oncology:癌胚抗原揭示结肠癌风险!

JAMA肿瘤学杂志12月21日在线发表的一项研究结果显示,结肠癌患者术前癌胚抗原(CEA)水平升高,切除后正常化的风险并不高。