Stroke:高血压患者颈动脉内膜厚度和首发脑卒中风险

2020-03-17 shaosai MedSci原创

本研究旨在评估高血压患者平均颈动脉内膜厚度(cIMT)与首发脑卒中风险的相关性,检查是否存在效应修正指标。

背景和目的

本研究旨在评估高血压患者平均颈动脉内膜厚度(cIMT)与首发脑卒中风险的相关性,检查是否存在效应修正指标。

方法

本研究共纳入了11547例无脑卒中病史的高血压患者。主要事件结果为出现首次脑卒中。

结果

在随访时间中位数为4.4年中,共有726例患者首次出现脑卒中,其中631例为缺血性脑卒中,90例患者为出血性脑卒中。平均cIMT每增加1SD与首次出现脑卒中(HR, 1.11 [95% CI, 1.03-1.20])、首次出现缺血性脑卒中(HR, 1.10 [95% CI, 1.01-1.20])具有显著正相关。另外,当cIMT按照四分位数进行分类,与四分位数1(≥0.66 mm)相比,首次发生脑卒中和出血性脑卒中在四分位数2-4(≥0.66 mm)间的风险更高。更重要地是,cIMT-首次脑卒中间的相关性在平均动脉压(≥109.3 [quintile 5] versus <109.3 mm Hg, P-interaction=0.024)较高或舒张压(≥90.7 [quintile 5] versus <90.7 mm Hg, P-interaction=0.009)较高的患者间更强。

结论

在高血压患者基线cIMT与首次发生脑卒中风险间具有正相关。在平均动脉压或收缩压较高的患者中两者的相关性更强。

原始出处:

Sun P, Liu L, Liu C  et al. Carotid Intima-Media Thickness and the Risk of First Stroke in Patients With Hypertension.DOI: 10.1161/STROKEAHA.119.026587

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    2020-03-17 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1708566, encodeId=dcf41e0856654, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Tue May 26 16:09:59 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843572, encodeId=795218435e2a2, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Mon Apr 13 02:09:59 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281342, encodeId=72131281342ee, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Thu Mar 19 05:09:59 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448301, encodeId=3fa4144830157, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Mar 19 05:09:59 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026594, encodeId=c0ad1026594f0, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Mar 17 17:09:59 CST 2020, time=2020-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045943, encodeId=f75b1045943cc, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Mar 17 17:09:59 CST 2020, time=2020-03-17, status=1, ipAttribution=)]
    2020-03-17 guging

    中风是俗称,应该称为缺血性卒中吧

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