JAHA:冠状动脉钙化和颈动脉斑块在预测心血管疾病上哪个更好?

2017-02-15 xing.T MedSci原创

CAC评分比颈动脉超声指标可以更好地改善心血管疾病和冠心病的预测、识别和重分类,虽然对脑卒中/TIA的预测和识别能力相似。

冠状动脉钙化(CAC)可以比颈动脉壁斑块更好地预测冠心病事件的发生;然而,在心血管疾病谱的事件中,运用CAC的负担和运用颈动脉斑块的负担之间的差异尚未有研究报道。近日,心血管疾病领域权威杂志JAHA上针对这一临床问题发表了一篇研究文章。

在研究之初,研究人员前瞻性地评估了无心血管疾病的多中心队列的心血管疾病、冠心病和脑卒中/短暂性脑缺血发作(TIA)事件。通过超声在颈总动脉、分叉处和颈内动脉段检测到的斑块数量来确定颈动脉斑块积分。CAC是通过CT检测来评估。预测值均采用Cox比例风险模型、C‐统计和净重分类进行比较,并且调整传统的心血管疾病危险因素。

在研究之初,4955名参与者的平均年龄(SD)为61.6(10.1)岁,52.8%为女性;48.9%的参与者CAC >0以及50.8%的参与者至少有1处颈动脉斑块。在11.3(3)年的随访期间,709名参与者发生心血管疾病,498名参与者发生冠心病,以及2628名参与者发生脑卒中或TIA事件。相比于颈动脉斑块,CAC评分具有更强的预测心血管疾病(风险比为1.78;95%可信区间为1.16-1.98;P<0.001 vs. 风险比为1.27;95%可信区间为1.16–1.40;P<0.001)、冠心病事件(风险比为2.09;95%可信区间为1.84–2.38;P < 0.001 vs. 风险比为1.35;95%可信区间为1.21–1.51;P<0.001)的能力。CAC评分与颈动脉斑块评分预测卒中/TIA的能力较弱。CAC评分比颈动脉斑块积分具有更好的重分类统计,除脑卒中/TIA外,其有相似的预测值。

由此可见,CAC评分比颈动脉超声指标可以更好地改善心血管疾病和冠心病的预测、识别和重分类,虽然对脑卒中/TIA的预测和识别能力相似。

原始出处:

Adam D. Gepner, et al. Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi‐Ethnic Study of Atherosclerosis. JAHA.2017. https://doi.org/10.1161/JAHA.116.005179

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    2017-02-17 zhaohui6731
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PAT是一个潜在的更年期‐特异性冠状动脉疾病的风险标志,并支持对中年女性这些脂肪组织进行监测和干预。

JACC子刊:冠状动脉钙化与CVD预后独立相关

目的:作者旨在确定基线冠状动脉钙化(CAC),随访CAC 及,CAC进展对心血管疾病(CVD)的影响。背景:重复CAC扫描已被提议作为跟踪总动脉粥样硬化负荷的方法。然而, CAC进展是否是未来心血管事件的预测因子尚不清楚。方法:这是一项前瞻性观察性研究,共5933名无心血管疾病患者,进行了2项检查,包括CAC评分,和随后的心血管事件的评估。用平方根法计算CAC的进展。主要终点为总体心血管事件(CV