Plasma Processes and Polymers:中国科研人员提供乳腺癌治疗新思路

2018-09-18 Wiley威立 Wiley威立

来自中国的一支研究团队开展了一项研究,该研究为在乳腺癌治疗中使用等离子体技术提供了新的思路。

来自中国的一支研究团队开展了一项研究,该研究为在乳腺癌治疗中使用等离子体技术提供了新的思路。

大气压冷等离子体(CAP)因其独特的多模态特征,已被广泛应用于细菌净化与创面愈合等医疗领域。在体外,CAP也对约20种癌症显示出潜在的抗癌功效。研究人员发现,同直接将癌细胞暴露于CAP一样,等离子体激活介质(PAM)(经等离子体处理的介质)也能有效地杀灭癌细胞。重要的是,与CAP直接处理相比,PAM更胜一筹的是可以避免外部的物理和化学损伤,如紫外线、热、电磁场和数十种活性反应组分,并且在冰箱中冷冻保存可以维持至少7天的活性,因此便于运输。

乳腺癌是一种异质性疾病,在全球范围内的发病率和死亡率不断上升。三阴性(TN)乳腺癌以其不良临床结果著称,并且因为缺乏药物表面标记,目前尚无有效的没有或有轻微副作用的靶向治疗方法。PAM作为一种具有剂量相关的癌细胞选择性的物理方法,如果适当控制,将是一种有前景的新型肿瘤治疗方法。在临床应用PAM治疗肿瘤之前,需要解决的关键问题是如何定义“剂量”以及在剂量与癌症细胞杀伤效果之间建立定量关系:目前还没有定量评估影响PAM抗肿瘤效果的因素,而且其抗肿瘤活性机制仍不清楚。



设备示意图与实验设置

不过,中国的一支科研团队通过18组正交实验和随后的线性模型构建,在机制研究方面取得了进展。在他们的研究中,他们确定了四个确定性参数,即“治疗时间”、“液体表面积”、“培养基厚度”和“细胞数量”,这些参数在等离子体的抗肿瘤功效上发挥决定性作用。该研究小组提出“活性组分扩散模型”和“信号转导模型”以解释等离子体处理介质的活性机理及其细胞凋亡诱导效果。此外,他们还建议使用确定性参数来定义液态等离子体的剂量,以更客观地反映其多模态特性。这项新研究以定量的方式阐明了等离子体的活性和功效,为其他与等离子体相关的研究提供了参考,推进了等离子体作为一种精确的肿瘤治疗方法,以及有效、安全的乳腺癌治疗方法的临床应用。

原始出处:
Xiaoyu Xu,  Xiaofeng Dai, Liangjian Xiang, et al. Quantitative assessment of cold atmospheric plasma anti‐cancer efficacy in triple‐negative breast cancers. Plasma Processes and Polymers. 15 May 2018.

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    2018-11-19 晓辰
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topicId=null, topicList=[TopicDto(id=16425, encryptionId=a75a1642585, topicName=SMA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569741, encodeId=d7471569e41ac, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
    2019-03-28 linlin2312
  4. 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  5. 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topicId=null, topicList=[TopicDto(id=16425, encryptionId=a75a1642585, topicName=SMA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569741, encodeId=d7471569e41ac, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
    2019-06-01 zhouqu_8
  6. 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topicId=null, topicList=[TopicDto(id=16425, encryptionId=a75a1642585, topicName=SMA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569741, encodeId=d7471569e41ac, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
    2019-03-04 anminleiryan
  7. 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content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 04 18:42:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346013, encodeId=87de3460137a, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Sep 21 12:16:55 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338472, encodeId=c45213384e210, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388882, encodeId=37461388882c5, content=<a href='/topic/show?id=a75a1642585' target=_blank style='color:#2F92EE;'>#SMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16425, encryptionId=a75a1642585, topicName=SMA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569741, encodeId=d7471569e41ac, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
    2018-09-21 wxl882001

    了解一下

    0

  8. 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content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 04 18:42:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346013, encodeId=87de3460137a, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Sep 21 12:16:55 CST 2018, time=2018-09-21, status=1, 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  9. 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topicId=null, topicList=[TopicDto(id=16425, encryptionId=a75a1642585, topicName=SMA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569741, encodeId=d7471569e41ac, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Thu Sep 20 05:42:00 CST 2018, time=2018-09-20, status=1, ipAttribution=)]
    2018-09-20 江川靖瑶
  10. 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    2018-09-20 dongjia2015

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