Lancet Public Health:降低饮用水砷浓度上限标准后每年可预防千例癌症发生

2017-10-31 佚名 肿瘤资讯

近期Lancet Public Health在线发表了来自美国国家健康与营养调查的数据,自2006年美国环保署(EPA)将公用水砷浓度上限标准从50ug/L下调至10ug/L后,每年可预防千例肺癌、膀胱癌和皮肤癌的发生。

近期Lancet Public Health在线发表了来自美国国家健康与营养调查的数据,自2006年美国环保署(EPA)将公用水砷浓度上限标准从50ug/L下调至10ug/L后,每年可预防千例肺癌、膀胱癌和皮肤癌的发生。

砷属于致癌物质,无机砷与肺癌、膀胱癌和皮肤癌发生及皮肤、心血管疾病有关。饮用水和饮食是人体内砷的主要来源。2006年,美国环保署(EPA)将公用水砷浓度上限标准从50ug/L下调至10ug/L。但是,在美国约4550万人使用私人水井的水,没有执行EPA砷浓度的标准。2000年EPA认为砷浓度上限定为50ug/L导致了1%和0.3%的肺癌和膀胱癌发生,但是自2006年调整砷浓度标准后的作用还不明确。

利用国家健康与营养调查(NHANES)数据库,评价2003年至2014年人群中砷的暴露水平。研究假设使用公用水人群尿砷浓度在下降,而使用私人水人群尿砷浓度不会下降。

调查性分析来自2003年至2014年NHANES的数据。NHANES由国家卫生统计中心负责,每2年调查一次。检测尿中砷的浓度。使用人类无机砷主要代谢产物二甲基砷酸(DMA)和尿砷来体现砷暴露的水平。

入组14127例,随访超过10年,共随访6周期,随着随访时间延长人种、种族在多样化,中位年龄在提高。使用公共用水人群,调整后的DMA水平从2003-04年的3·01 μg/L下降至2013–14年的2·49 μg/L(下降17%,95%CI10~24,P<0.01),但在使用私人水的人群中未看到这种变化(P=0.35)。医生估计可以每年可预防200~900例肺癌和膀胱癌、50例皮肤癌。DMA水平2003-04年与2009-10年间无区别(3.01 ug/L和2.93 ug/L),但到了2011-12年和2013–14年尿中DMA下降,分别为2.64 ug/L和2.49 ug/L。

通过NHANES2003年至2014年的调查,使用公用水人群尿砷水平下降17%,但使用私人水的人群尿砷水平未见下降。降低饮用水砷浓度上限后可预防癌症的发生。

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    2018-03-05 shizhenshan
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    2017-12-28 howi
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    2017-11-02 lishizhe
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