第十七届中国介入心脏病学大会(CIT2019)|侯玉清:NSTE-ACS介入治疗的时机与策略

2019-03-30 Gill MedSci原创

非ST段抬高型急型冠状动脉综合征(NSTE-ACS)行造影可见局部血栓或狭窄,尚存在部分血流。判断ACS主要根据:1.临床典型症状;2.心电图典型表现;3;肌钙蛋白升高。还应注意,心梗三项自2014年起欧洲指南起不推荐用于ACS诊断。目前有大量RCT研究证明,对于ST段抬高型急型冠状动脉综合征(STE-ACS)应该尽早进行介入治疗,此类患者多为中青年;而非ST段抬高型急型冠状动脉综合征(NSTE-

非ST段抬高型急型冠状动脉综合征(NSTE-ACS)行造影可见局部血栓或狭窄,尚存在部分血流。判断ACS主要根据:1.临床典型症状;2.心电图典型表现;3;肌钙蛋白升高。还应注意,心梗三项自2014年起欧洲指南起不推荐用于ACS诊断

目前有大量RCT研究证明,对于ST段抬高型急型冠状动脉综合征(STE-ACS)应该尽早进行介入治疗,此类患者多为中青年;而非ST段抬高型急型冠状动脉综合征(NSTE-ACS)的患者大多数为高龄人群或合并糖尿病、肾病等。一项名为After Eighty的研究旨在分析年龄大于80岁人群的ACS特点,研究纳入457例NSTEMI或UAP,随机分组后,228例患者进入保守治疗组,而229例患者进入介入治疗组;结果显示对于年龄大于80岁的ACS患者,介入治疗的生存获益大于保守治疗。

2014年美国AHA/ACC指南针对NSTE-ACS介入治疗的时机与策略作出明确建议,对于极高危伴有严重心衰或心律失常患者应在2小时内行介入治疗。欧洲心脏病学会(ESC)年会于2015年公布了新版非ST段抬高型急性冠脉综合征(NSTE-ACS)管理指南--对于高危患者应在2小时内行介入治疗,对于中危患者应24小时内,而低危患者应在72小时之内。务必牢记这三个危险分层和时间节点,选择适当的治疗方式,避免不必要的临床纠纷。
存在至少下列一项表现的高危患者,推荐立即(<2h)介入治疗:血流动力学不稳定或心源性休克;再发性或药物治疗难于缓解的持续性胸痛,危及生命的心律失常或心跳骤停,心梗的机械性并发症,急性心衰,ST-T动态改变。
存在至少以下一项表现中危患者,推荐早期(<24h)介入治疗:肌钙蛋白水平升高或降低与心梗一致;动态ST或T波改变(有或无症状),GRACE评分>140。
存在至少以下一项表现的低危患者,推荐(<72h)介入治疗:糖尿病;肾功能不全;LVEF<40%或充血性心衰,梗死后早期心绞痛,近期PCI史,之前CABG,GRACE评分>109且<140。
总而言之,对于NSTEMI是否行介入或保守治疗主要取决于临床症状、体征、生物标记物、工具评分,并结合自身导管室条件后综合决策。对于ACS管理目前尚存在争议,对于高危患者早期介入治疗获益较大,应尽早介入治疗。运用低分子肝素、抗血小板药物、他汀药物和新型优良支架都对患者预后有益。对于疑难病例应首先对病情进行准确的判断,合并高危并发症的患者,在术前对知情同意书进行透彻沟通与谈判,保护自身安全。
若想获知关于本次大会更多精彩内容,敬请期待梅斯医学后续报道。

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    2019-11-22 qblt
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    2019-04-20 drj2003
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    2019-04-09 1259d396m56暂无昵称

    谢谢分享学习

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    2019-04-01 清风拂面

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    2019-04-01 yaanren

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