阜外学者构建中国心衰患者搭桥死亡风险模型:仅纳入7个指标,适合临床推广

2019-05-31 xujing 中国循环杂志

目前,国内外主要心脏手术风险评分模型对于心力衰竭患者行CABG的风险评估针对性不强。

目前,国内外主要心脏手术风险评分模型对于心力衰竭患者行CABG的风险评估针对性不强。

阜外医院侯剑峰等研究发现,EuroSCORE、EuroSCOREⅡ以及针对中国人群的SinoSCORE不能准确预测心力衰竭患者行CABG的院内死亡率,会明显高估死亡率。

研究者构建了中国心力衰竭人群的CABG风险评估系统(PGLANCE),包括7个指标:性别、既往心脏手术史、血肌酐值、术前LVEF值、术前NYHA心功能分级、是否合并瓣膜手术、是否同期行主动脉手术。

研究者分析,PGLANCE对心力衰竭患者行CABG死亡率表现出较好的预测效果:HL拟合优度检验为P=0.311,AUC=0.847,效果优于EuroSCORE(AUC:0.775)、SinoSCORE(AUC:0.698),接近于EuroSCOREⅡ(AUC:0.878)。

在验证组中,仅PGLANCE预测死亡率95%可信区间包含实际观察值,明显优于其他三种评分系统。

研究者收集阜外医院自2012年至2017年接受CABG的1976 例术前心力衰竭(LVEF<50%)患者的临床资料。入选患者以3:1的比例随机分为2组:建模组(n=1 479)用于建立模型,验证组(n=497)用于检测模型的可用性。应用Logistic回归的统计学方法建立新的评分系统(PGLANCE)。


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    2019-05-31 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0