Nat Commun:基因表达模式或可以帮助确定死亡时间

2018-02-14 佚名 生物360

据《自然 - 通讯》发表的一篇论文报告,死亡引起的不同组织的基因表达变化可用于估计死者的死亡时间。

据《自然 - 通讯》发表的一篇论文报告,死亡引起的不同组织的基因表达变化可用于估计死者的死亡时间

该研究认为通过分析少量可用的组织(如肺或皮肤组织),可以准确确定死者的死亡时间,这或将对法医鉴定产生一定影响。 为了了解一个人死后的组织特异性基因表达变化,Roderic Guigó与同事分析了来自 GTEx 项目的 36 种不同组织的 RNA 测序数据(GTEx 项目是一个收集人类死后组织样本的生物库)。

他们表明死亡时间会对基因表达产生影响,而且对不同的组织影响不一样。作者开发了一种模型来根据这些组织特异性基因表达变化估计死亡时间,有望对现行方法起到补充作用。 作者进一步优化了模型,使之适用于法医鉴定场景(一般可能只有少数组织可用),并为其在法医病理学中的潜在应用设计了一种方案。

原始出处:

Pedro G. Ferreira, Manuel Muoz-Aguirre, Ferran Reverter,et al. The effects of death and post-mortem cold ischemia on human tissue transcriptomes. Nature Communicationsvolume 9, Article number: 490 (2018), doi:10.1038/s41467-017-02772-x.

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    2018-07-21 liuli5079
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    2018-11-23 liye789132251
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    2018-02-15 changjiu

    学习一下谢谢

    0

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    2018-02-14 神功盖世

    0

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