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Acta Inform Med：陶瓷之间可促进干细胞的增殖分化或可用于骨缺损的修复

2019-11-28 不详 网络

关注

支架是在组织工程应用中再生新的骨骼和骨骼组织生长的地方。hADMSC是一种能分化为成骨，成软骨和成脂细胞的多能细胞。Y-TZP由于其坚硬的特性（即断裂韧性和高弯曲强度）而被证明比其他陶瓷具有多个优势。本研究旨在通过体外分析来分析Y-TZP作为hADMSCs接种的支架的生物相容性。这项研究涉及多个过程，即Y-TZPS制造过程，XRD检查，hADMSC的区分和表征，SEM观察以及TT。XRD结果显示，

支架是在组织工程应用中再生新的骨骼和骨骼组织生长的地方。hADMSC是一种能分化为成骨，成软骨和成脂细胞的多能细胞。Y-TZP由于其坚硬的特性（即断裂韧性和高弯曲强度）而被证明比其他陶瓷具有多个优势。

本研究旨在通过体外分析来分析Y-TZP作为hADMSCs接种的支架的生物相容性。这项研究涉及多个过程，即Y-TZPS制造过程，XRD检查，hADMSC的区分和表征，SEM观察以及TT。

XRD结果显示，Y-TZPS具有尖峰。这表明它们具有较高的晶体纯度。hADMSC表征显示，NMT上方的CD 90，CD 73和CD 105，以及CD 14，CD 19，CD 34，CD 45和HLA- DR低于NLT。随后用SEM对Y-TZPS的观察结果进行分析，结果表明Y-TZPS具有孔隙，HADMSCs粘附并在Y-TZPS孔隙中增殖。

综上所述，该研究结果表明，低孔隙度和毒性的Y-TZPS能够促进hADMSC的增殖和分化。预期将使用具有高生物相容性的hADMSC将Y-TZPSs用作可植入生物材料。

原始出处：

Rachman A, Rantam FA, et al., Biocompatibility of Yttria-Tetragonal Zirconia Polycrystal Seeded with Human Adipose Derived Mesenchymal Stem Cell. Acta Inform Med. 2018 Dec;26(4):249-253. doi: 10.5455/aim.2018.26.249-253.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1776979, encodeId=5c661e76979e8, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sun Dec 15 04:57:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849806, encodeId=2bed1849806e4, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Dec 24 17:57:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025365, encodeId=11f4102536569, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Dec 01 15:57:00 CST 2019, time=2019-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419339, encodeId=d70714193395a, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610149, encodeId=e024161014933, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-12-15 redcrab

    #陶瓷#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1776979, encodeId=5c661e76979e8, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sun Dec 15 04:57:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849806, encodeId=2bed1849806e4, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Dec 24 17:57:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025365, encodeId=11f4102536569, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Dec 01 15:57:00 CST 2019, time=2019-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419339, encodeId=d70714193395a, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610149, encodeId=e024161014933, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-12-24 windight

    #CTA#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1776979, encodeId=5c661e76979e8, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sun Dec 15 04:57:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849806, encodeId=2bed1849806e4, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Dec 24 17:57:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025365, encodeId=11f4102536569, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Dec 01 15:57:00 CST 2019, time=2019-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419339, encodeId=d70714193395a, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610149, encodeId=e024161014933, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-12-01 独孤立克

    干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1776979, encodeId=5c661e76979e8, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sun Dec 15 04:57:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849806, encodeId=2bed1849806e4, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Dec 24 17:57:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025365, encodeId=11f4102536569, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Dec 01 15:57:00 CST 2019, time=2019-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419339, encodeId=d70714193395a, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610149, encodeId=e024161014933, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-11-30 lfcmxl

    #骨缺损#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1776979, encodeId=5c661e76979e8, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sun Dec 15 04:57:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849806, encodeId=2bed1849806e4, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Dec 24 17:57:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025365, encodeId=11f4102536569, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Dec 01 15:57:00 CST 2019, time=2019-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419339, encodeId=d70714193395a, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610149, encodeId=e024161014933, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Nov 30 06:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-11-30 ms3994565386320060

    #Med#

    0