Sci Rep:MAOA,一个新的激素抵抗性神经内分泌前列腺癌细胞凋亡和自我吞噬的决定者

2017-04-13 AlexYang MedSci原创

自我吞噬和细胞凋亡是两个精细的控制机制来调控细胞的命运。但是,人们对细胞命运走向决定因子的理解还在初期。单胺氧化酶A(MAOA)是一个线粒体酶,且在精神病研究中被人熟知。越来越多的报道表明了MAOA的超表达与前列腺癌(PCa)有关。最近,研究人员展示了MAOA参与了PCa细胞神经内分泌分化的调控,并且该细胞为激素抵抗性PCa(HRPC),是一种致死的疾病类型。接着,最近的报道展示了PCa的神经内分

自我吞噬和细胞凋亡是两个精细的控制机制来调控细胞的命运。但是,人们对细胞命运走向决定因子的理解还在初期。

单胺氧化酶A(MAOA)是一个线粒体酶,且在精神病研究中被人熟知。越来越多的报道表明了MAOA的超表达与前列腺癌(PCa)有关。最近,研究人员展示了MAOA参与了PCa细胞神经内分泌分化的调控,并且该细胞为激素抵抗性PCa(HRPC),是一种致死的疾病类型。接着,最近的报道展示了PCa的神经内分泌分化需要抑制元件1沉默转录因子(REST)的下调和吞噬的激活。研究人员发现,MAOA是REST的一个新的直接靶标基因。MAOA的超表达产生的活性氧类(ROS)在抑制凋亡和激活神经内分泌分化PCa细胞的吞噬中起重要作用,而MAOA的抑制子可以显着的减少PCa细胞的神经内分泌分化和自我吞噬。最后,研究人员指出,他们的研究结果展示了MAOA是一个新的激活自我吞噬的决定因子。并且,MAOA的抑制子也许是很有用的,可作为神经内分泌肿瘤的一个潜在的疗法。

原始出处:

Yi-Cheng Lin, Yi-Ting Chang, Mel Campbell et al. MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. Sci Rep. 12 April 2017. doi:10.1038/srep46338.

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    2017-04-28 gwc392
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    2018-03-25 yige2012
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  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40011656268, createdName=121485632188547785, createdTime=Sat Apr 15 13:51:57 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252221, encodeId=df06125222134, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sat Apr 15 07:12:00 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340246, encodeId=8a621340246f3, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187329, encodeId=6e1518e32995, content=学习了很好非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=650f104372, createdName=gcwu82, createdTime=Fri Apr 14 11:45:14 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-22 sword20000

    应用于临床者寥寥无几。

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187329, encodeId=6e1518e32995, content=学习了很好非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=650f104372, createdName=gcwu82, createdTime=Fri Apr 14 11:45:14 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-15 虈亣靌

    学习了很好的内容

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187329, encodeId=6e1518e32995, content=学习了很好非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=650f104372, createdName=gcwu82, createdTime=Fri Apr 14 11:45:14 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-15 121485632188547785

    自我吞噬和细胞凋亡是两个精细的控制机制来调控细胞的命运。

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187329, encodeId=6e1518e32995, content=学习了很好非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=650f104372, createdName=gcwu82, createdTime=Fri Apr 14 11:45:14 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-15 yxch36
  8. 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  9. 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  10. 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    2017-04-14 gcwu82

    学习了很好非常感谢

    0

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