Diabetes Care:2型糖尿病患者若没有外周脉搏,可要警惕了!

2016-10-19 MedSci MedSci原创

2型糖尿病患者的血管性疾病负担仍然相当大,还需要对相关风险标志物进行相关的进一步识别。 对于2型糖尿病患者,缺乏足背和胫后脉冲,是否是主要大血管和微血管事件、死亡和认知能力下降的预测因素? 数据来自11120例患者,均来自ADVANCE研究。基线无外周脉搏定义为:至少缺少一个足背或胫后脉冲。 多因素校正后,无外周脉搏与存在外周脉搏(n = 2,218)相比,与以下事件的5年风险增

2型糖尿病患者的血管性疾病负担仍然相当大,还需要对相关风险标志物进行相关的进一步识别。

对于2型糖尿病患者,缺乏足背和胫后脉冲,是否是主要大血管和微血管事件、死亡和认知能力下降的预测因素?

数据来自11120例患者,均来自ADVANCE研究。基线无外周脉搏定义为:至少缺少一个足背或胫后脉冲。

多因素校正后,无外周脉搏与存在外周脉搏(n = 2,218)相比,与以下事件的5年风险增加有关:主要大血管事件(HR 1.47 [95%CI 1.28–1.69], P < 0.0001)、心肌梗死(1.45 [1.13–1.87], P = 0.003)、卒中(1.57 [1.23–2.00], P = 0.0003)、心血管死亡(1.61 [1.33–1.95], P < 0.0001)、心衰(1.49 [1.21–1.84], P = 0.0002)、全因死亡率(1.48 [1.29–1.71], P < 0.0001)、主要微血管事件(1.17 [1.00–1.36], P = 0.04)、肾病
(1.24 [1.00–1.54], P = 0.04)、终末期肾脏疾病或肾死亡(2.04 [1.12–3.70], P = 0.02)、周围神经病变(1.13 [1.05–1.21], P = 0.0008)。

不管是缺乏足背还是胫后脉冲,参与者的风险比具有可比性。风险增加的多少,与缺乏足背或胫后脉冲数目的多少是成比例的。缺乏3-4次的患者,风险最高;缺乏外周脉搏的数目每增加一个,所有结局的风险都会增加。

结果表明,无足背和胫后脉冲是2型糖尿病患者主要血管事件的独立预测因子。临床上使用这些简单的指标,可以对患者进行危险分层、治疗,以及改善患者结局。

原始出处:

Kamel Mohammedi,et al.Absence of Peripheral Pulses and Risk of Major Vascular Outcomes in Patients With Type 2 Diabetes.Diabetes Care 2016 Sep

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    2016-10-21 yebin0307

    是否也会与糖尿病足相关?

    0

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    2016-10-20 399

    基层医院,该项检查能做,但医务人员的意识尚不到位,需要培训!

    0

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    2016-10-19 inter158

    该风险还是挺大的。

    0

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