CLIN CANCER RES:DC-CIK免疫治疗联合S-1化疗治疗晚期胰腺癌

2017-09-07 MedSci MedSci原创

晚期胰腺癌患者如何有效进行治疗一直是一个巨大的挑战。CLIN CANCER RES近期发表了一篇文章,研究DC-CIK免疫疗法联合S-1化疗治疗这种恶性疾病的安全性和临床效果。

晚期胰腺癌患者如何有效进行治疗一直是一个巨大的挑战。CLIN CANCER RES近期发表了一篇文章,研究DC-CIK免疫疗法联合S-1化疗治疗这种恶性疾病的安全性和临床效果。47例晚期胰腺癌患者分别接受DC-CIK+S-1,单独DC-CIK,单独S-1或支持治疗。研究结果表明,DC-CIK联合S-1化疗显着延长患者平均总生存期和无进展生存期(212和136天),单独DC-CIK(128和85天),单纯化疗为(141和92天),支持治疗(52和43天)。调整了危险因素后,DC-CIK联合S-1化疗以及接受2个周期及以上DC-CIK治疗是无病生存和总生存的独立预测因素。PBMCs亚型分析表明DC-CIK细胞治疗后CD3+,CD3+/CD4+以及CD8+/CD28+T细胞亚群增加,而CD3+/CD8+,CD3+/CD16+/CD56+和CD4+/CD25+细胞亚群显着下降。无3级或4级毒性反应。此外,14例接受DC-CIK治疗患者中4例出现循环肿瘤细胞DNA下降,且与生存改善有关。文章最后认为,DC-CIK联合S-1化疗治疗晚期胰腺癌是安全的,可以改善患者无进展生存和总生存情况,并调节外周

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    2017-09-10 luominglian113

    学习了.谢谢分享

    0

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    2017-09-07 随梦飞扬

    DC-CIK联合S-1化疗治疗晚期胰腺癌是安全的.可以改善患者无进展生存和总生存情况.并调节外周血免疫组份.

    0

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    2017-09-07 随梦飞扬

    单独DC-CIK(128和85天)

    0

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    2017-09-07 随梦飞扬

    DC-CIK联合S-1化疗显着延长患者平均总生存期和无进展生存期(212和136天)

    0

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    2017-09-07 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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